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Titolo:
PATHOPHYSIOLOGICAL BASIS OF VULNERABILITY TO DRUG-ABUSE - ROLE OF AN INTERACTION BETWEEN STRESS, GLUCOCORTICOIDS, AND DOPAMINERGIC-NEURONS
Autore:
PIAZZA PV; LEMOAL M;
Indirizzi:
UNIV BORDEAUX 2,INSERM U259,DOMAINE CARREIRE,RUE CAMILLE ST SAENS F-33077 BORDEAUX FRANCE
Titolo Testata:
Annual review of pharmacology and toxicology
, volume: 36, anno: 1996,
pagine: 359 - 378
SICI:
0362-1642(1996)36:<359:PBOVTD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHEDULE-INDUCED-POLYDIPSIA; INDUCED LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; INDIVIDUAL-DIFFERENCES; RAT-BRAIN; CORTICOSTERONE SECRETION; INDUCED SENSITIZATION; PREFRONTAL CORTEX; MOTOR-ACTIVITY; D-AMPHETAMINE;
Keywords:
INDIVIDUAL DIFFERENCES; CORTICOSTERONE; AMPHETAMINE; COCAINE; MORPHINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
117
Recensione:
Indirizzi per estratti:
Citazione:
P.V. Piazza e M. Lemoal, "PATHOPHYSIOLOGICAL BASIS OF VULNERABILITY TO DRUG-ABUSE - ROLE OF AN INTERACTION BETWEEN STRESS, GLUCOCORTICOIDS, AND DOPAMINERGIC-NEURONS", Annual review of pharmacology and toxicology, 36, 1996, pp. 359-378

Abstract

Research on drug abuse has recently focused on understanding the vulnerability to develop addiction that is present in certain individuals. These investigations suggest that addiction results from an interaction between drugs and specific individual substrates. Differences in the propensity to develop drug intake can be demonstrated in animals with equal access to drugs under stable laboratory conditions and can be predicted by drug-independent behaviors. Stress, corticosterone, and mesencephalic dopaminergic neurons seem to be organized in a pathophysiological chain determining such a vulnerability. An increased corticosterone secretion, or a higher sensitivity to the effects of this hormone, either naturally present in certain individuals or induced by stress in others, increases the vulnerability to develop drug intake, via an enhancement of the activity of mesencephalic dopaminergic neurons. These findings suggest that addiction therapies should counteract the biological peculiarity that leads some individuals to respond in a pathophysiological way to drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:29:54