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Titolo:
NEW PHARMACOLOGICAL STRATEGIES FOR PAIN RELIEF
Autore:
DRAY A; URBAN L;
Indirizzi:
ASTRA PAIN RES UNIT,275 BOUL ARMAND FRAPPIER LAVAL PQ CANADA SANDOZ INST MED RES LONDON WC1E 6BN ENGLAND
Titolo Testata:
Annual review of pharmacology and toxicology
, volume: 36, anno: 1996,
pagine: 253 - 280
SICI:
0362-1642(1996)36:<253:NPSFPR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; GENE-RELATED PEPTIDE; NK1 RECEPTOR ANTAGONIST; RAT SPINAL-CORD; SUBSTANCE-P; SENSORY NEURONS; MOLECULAR MECHANISMS; POTASSIUM CHANNELS; ANALGESIC AGENTS; AGONIST ACTIVITY;
Keywords:
ANALGESIA; INFLAMMATION; NERVE INJURY; NERVOUS SYSTEM; NEUROCHEMISTRY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
193
Recensione:
Indirizzi per estratti:
Citazione:
A. Dray e L. Urban, "NEW PHARMACOLOGICAL STRATEGIES FOR PAIN RELIEF", Annual review of pharmacology and toxicology, 36, 1996, pp. 253-280

Abstract

The recent advances made in elucidating the processes of nociception have altered the way that chronic pain therapy and analgesic drug development are approached. Recent studies have highlighted new targets for drug discovery, including inhibition of inflammatory mediators (kinins, growth factors), newly expressed proteins (B-1 receptors, COX-2), and blockers of afferent fiber activity (capsaicin analogues, ion channel blockers). In the CNS, a further multiplicity of strategies can bepursued, including the development of antagonists of specific neuropeptide and glutamate receptors or agonists for purine and amine receptors. Such drugs will inevitably supplement or replace conventional NSAID and opioid analgesics. Further characterization of gene regulation will allow the development of drugs that genetically modify cellular activity altered by chronic pain conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:01:10