Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CARDIAC ACTIONS OF ANTIHISTAMINES
Autore:
WOOSLEY RL;
Indirizzi:
GEORGETOWN UNIV,MED CTR,INST CARDIOVASC SCI,DEPT PHARMACOL WASHINGTONDC 20007 GEORGETOWN UNIV,MED CTR,DEPT MED WASHINGTON DC 20007
Titolo Testata:
Annual review of pharmacology and toxicology
, volume: 36, anno: 1996,
pagine: 233 - 252
SICI:
0362-1642(1996)36:<233:CAOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; III ANTIARRHYTHMIC AGENTS; LONG QT-SYNDROME; ASTEMIZOLE OVERDOSE; ELECTROCARDIOGRAPHIC PHARMACODYNAMICS; EARLY AFTERDEPOLARIZATIONS; MAJOR METABOLITES; TERFENADINE; PHARMACOKINETICS; QUINIDINE;
Keywords:
ARRHYTHMIA; TERFENADINE; ASTEMIZOLE; POTASSIUM CHANNELS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Woosley, "CARDIAC ACTIONS OF ANTIHISTAMINES", Annual review of pharmacology and toxicology, 36, 1996, pp. 233-252

Abstract

Two of the nonsedating antihistaminic drugs, terfenadine and astemizole, have recently been recognized in rare cases to induce the syndromeof torsades de pointes, i.e. QT interval prolongation and life-threatening ventricular tachycardia. Each was found to prolong cardiac repolarization when its metabolic elimination was impaired, such as by liver disease or drugs that inhibit the 3A family of cytochrome P450. In vitro studies indicate that this action is due to blockade of one or more of the cardiac potassium channels that determine the duration of the action potential. Prescription guidelines are now available to reduce the risk of developing arrhythmias with these two drugs. Two agents recently marketed in the United States, loratidine and cetirizine, appear to lack the ability to prolong repolarization and induce torsades de pointes. Evaluation of the potential cardiac actions of investigational antihistamines is essential and may be of value for some of the older conventional agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:07:14