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Titolo:
IS THE INPUT TO A GABAERGIC SYNAPSE THE SOLE ASYMMETRY IN TURTLES RETINAL DIRECTIONAL SELECTIVITY
Autore:
SMITH RD; GRZYWACZ NM; BORGGRAHAM LJ;
Indirizzi:
SMITH KETTLEWELL EYE RES INST,2232 WEBSTER ST SAN FRANCISCO CA 94115 SMITH KETTLEWELL EYE RES INST SAN FRANCISCO CA 94115 MIT,CTR BIOL INFORMAT PROC CAMBRIDGE MA 02139
Titolo Testata:
Visual neuroscience
fascicolo: 3, volume: 13, anno: 1996,
pagine: 423 - 439
SICI:
0952-5238(1996)13:3<423:ITITAG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; COMPLEX RECEPTIVE-FIELDS; STARBURST AMACRINE CELLS; GANGLION-CELLS; RABBIT RETINA; FUNCTIONAL INTERPRETATION; DENDRITIC MORPHOLOGY; BIPOLAR CELLS; NEURONS; CLASSIFICATION;
Keywords:
DIRECTIONAL SELECTIVITY; RETINAL GANGLION CELLS; GABA; PREFERRED-DIRECTION FACILITATION; NULL-DIRECTION INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Smith et al., "IS THE INPUT TO A GABAERGIC SYNAPSE THE SOLE ASYMMETRY IN TURTLES RETINAL DIRECTIONAL SELECTIVITY", Visual neuroscience, 13(3), 1996, pp. 423-439

Abstract

We examined the effects of picrotoxin and pentylenetetrazol (PTZ) on the responses to motions of ON-OFF directionally selective (DS) ganglion cells of the turtle's retina. These drugs are antagonists of the inhibitory neurotransmitter GABA. For continuous motions, picrotoxin markedly reduced the overall directionality of the cells. In 21% of the cells, directional selectivity was lost regardless of speed and contrast. However, other cells maintained their preferred direction despite saturating concentrations of picrotoxin. And in most cells, loss, maintenance, or even reversal of preferred and null directions could occur as speed and contrast were modulated. In 50% of the cells, reversal ofpreferred and null directions occurred at some condition of visual stimuli. However, picrotoxin did not tend to alter the preferred-null axis for directional selectivity. For apparent motions, picrotoxin made motion facilitation, which normally occurs exclusively in preferred-direction responses, to become erratic and often occur during null-direction motions. Finally, PTZ had effects similar to picrotoxin but with less potency. The results in this paper indicated that models of directional selectivity based solely on a GABAergic implementation of Barlow and Levick's asymmetric-inhibition model do not apply to the turtle retina. Alternative models may comprise multiple directional mechanisms and/or a symmetric inhibitory one, but not asymmetric facilitation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:09:19