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Titolo:
CELLULAR-RESPONSES TO ENTEROPATHOGENIC ESCHERICHIA-COLI INFECTION
Autore:
KNUTTON S;
Indirizzi:
UNIV BIRMINGHAM,INST CHILD HLTH,FRANCIS RD BIRMINGHAM B16 8ET W MIDLANDS ENGLAND
Titolo Testata:
Bioscience reports
fascicolo: 6, volume: 15, anno: 1995,
pagine: 469 - 479
SICI:
0144-8463(1995)15:6<469:CTEEI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUNDLE-FORMING PILUS; TISSUE-CULTURE CELLS; HEP-2 CELLS; EPITHELIAL-CELLS; EFFACING LESIONS; HELA-CELLS; ADHERENCE; PLASMID; GENE; PROTEIN;
Keywords:
ENTEROPATHOGENIC ESCHERICHIA COIL; ATTACHING AND EFFACING LESIONS; EPITHELIAL CELLS; BACTERIAL PATHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
S. Knutton, "CELLULAR-RESPONSES TO ENTEROPATHOGENIC ESCHERICHIA-COLI INFECTION", Bioscience reports, 15(6), 1995, pp. 469-479

Abstract

Enteropathogenic Escherichia coli (EPEC), first described in the 1940's and 1950s, remain an important cause of severe infantile diarrhoea in many parts of the developing world. EPEC do not produce enterotoxins and are not invasive; instead their virulence depends upon exploitation of host cell signalling pathways and the host cell cytoskeleton both as a means of colonizing mucosal surfaces of the small intestine and causing diarrhoea. Following initial mucosal attachment, EPEC secrete 'signalling' proteins and expresss a surface adhesin, intimin, to produce 'attaching & effacing' lesions in the enterocyte brush border membrane characterised by localised destruction of brush border microvilli, intimate bacterial adhesion and cytoskeletal reorganisation and accretion beneath attached bacteria. The pathophysiology of EPEC diarrhoea is also complex and probably results from a combination of epithelial cell responses including both electrolyte secretion and structural damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:50:30