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Titolo:
PROSTATIC ACID-PHOSPHATASE LEVELS (ENZYMATIC METHOD) FROM COMPLETELY SECTIONED, CLINICALLY BENIGN, WHOLE PROSTATES
Autore:
BRAWN PN; JAY DW; FOSTER DM; KUHL D; SPEIGHTS VO; JOHNSON EH; RIGGS M; LIND ML; COFFIELD KS; WEAVER B;
Indirizzi:
UNIV MICHIGAN,VET ADM MED CTR,DEPT PATHOL ANN ARBOR MI 48105 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP,SCH MED,VET ADM MED CTR,DEPT PATHOL TEMPLE TX 76508 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP,SCH MED,DEPT STAT TEMPLE TX 76508 TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP,SCH MED,DEPT UROL TEMPLE TX 76508 TEMPLE JR COLL,VET ADM MED CTR,DEPT PATHOL TEMPLE TX 00000 BAYLOR UNIV,INST BIOMED STUDIES,VET ADM MED CTR,DEPT NUCL MED WACO TX76798 KELSEY SEYBOLD CLIN,DEPT RES & EDUC HOUSTON TX 00000
Titolo Testata:
The Prostate
fascicolo: 5, volume: 28, anno: 1996,
pagine: 295 - 299
SICI:
0270-4137(1996)28:5<295:PAL(MF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL HYPERPLASIA; RADIOIMMUNOASSAY; ADENOCARCINOMA; ADENOSIS; ANTIGEN; SERUM;
Keywords:
PROSTATE CARCINOMA; ACID PHOSPHATASE; ATYPICAL HYPERPLASIA/ADENOSIS; PROSTATIC ACID PHOSPHATASE; PROSTATIC INTRAEPITHELIAL NEOPLASIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Brawn et al., "PROSTATIC ACID-PHOSPHATASE LEVELS (ENZYMATIC METHOD) FROM COMPLETELY SECTIONED, CLINICALLY BENIGN, WHOLE PROSTATES", The Prostate, 28(5), 1996, pp. 295-299

Abstract

Clinically benign, whole, untrimmed prostates were obtained from 104 patients at autopsy, completely sectioned, and examined microscopically. The histological and gross findings of the prostate were correlatedwith premortem prostatic acid phosphatase levels (PAP, enzymatic method, ACA, Dupont Co.) to determine how often carcinoma of the prostate (CAP) affected PAP levels and to identify other findings within the prostate associated with elevated PAP levels. Sixty (58%) prostates did not have CAP, 34 (33%) had CAP smaller than 1 mi in volume, and 10 (10%) had CAP larger than 1 mi in volume. PAP levels were elevated (greater than 1 U/L) in 8 of the 60 (13%) prostates without CAP, in 2 of the34 (6%) prostates with CAP smaller than 1 mi, and in 1 of the 10 (10%) prostates with CAP larger than 1 mi. These differences were not statistically significant. Likewise, a statistically significant correlation between PAP levels and patient age, patient race, severe inflammation, or high grade prostatic intraepithelial neoplasia (PIN) was not found. However, there was a statistically significant correlation between PAP levels and prostate weight (P < 0.0001). This study suggests that PAP cannot distinguish between patients with clinically undetected CAP and patients without CAP.]Furthermore, elevated PAP levels are often not due to metastatic CAP and additional evidence should be present,even in patients with known CAP, before an elevated PAP level is considered to be conclusive evidence of metastatic CAP. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 15/07/20 alle ore 08:47:32