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Titolo:
NORADRENERGIC MECHANISMS IN STRESS AND ANXIETY .2. CLINICAL-STUDIES
Autore:
BREMNER JD; KRYSTAL JH; SOUTHWICK SM; CHARNEY DS;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,NATL CTR PTSD W HAVEN CT 06516 VET ADM MED CTR W HAVEN CT 06516
Titolo Testata:
Synapse
fascicolo: 1, volume: 23, anno: 1996,
pagine: 39 - 51
SICI:
0887-4476(1996)23:1<39:NMISAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-2-ADRENERGIC RECEPTOR-BINDING; OBSESSIVE-COMPULSIVE DISORDER; VIETNAM COMBAT VETERANS; PANIC DISORDER; HEALTHY-SUBJECTS; BEHAVIORAL-INHIBITION; PLASMA-CATECHOLAMINES; CEREBRAL METABOLISM; ANXIOUS PATIENTS; URINARY MHPG;
Keywords:
ANXIETY; NORADRENERGIC FUNCTION; POSTTRAUMATIC STRESS DISORDER; PANIC DISORDER; GENERALIZED ANXIETY DISORDER; OBSESSIVE-COMPULSIVE DISORDER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
118
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Bremner et al., "NORADRENERGIC MECHANISMS IN STRESS AND ANXIETY .2. CLINICAL-STUDIES", Synapse, 23(1), 1996, pp. 39-51

Abstract

Studies in animals have shown a relationship between alterations in noradrenergic brain system function and behaviors of anxiety and fear. These findings have generated the hypothesis that the symptoms seen inpatients with anxiety disorders may be related to alterations in noradrenergic function. A number of clinical studies have tested this hypothesis, utilizing measures of catecholaminergic function such as heartrate and blood pressure, measurement of norepinephrine and its metabolites in urine and plasma and adrenergic receptor binding in platelets, as well as pharmacological challenge to the noradrenergic system. Acute stressors, such as public speaking, have been associated with an increase in heart rate, blood pressure, and norepinephrine and its metabolites in urine and plasma. Findings in patients with panic disorder at baseline related to heart rate, blood pressure, baseline norepinephrine and its metabolites, and platelet adrenergic receptors have been mixed, while the most consistent findings have been blunted growth hormone response to clonidine and increased 3-methoxy-4-hydroxy-phenylethylene-glucol (MHPG) and anxiety following stimulation of the noradrenergic system with yohimbine. Baseline measures of noradrenergic function in patients with posttraumatic stress disorder (PTSD) have also beenmixed, while an increased heart, blood pressure and norepinephrine response to traumatic reminders, as well as increased behavioral (as well as different brain metabolic) response to yohimbine, have been foundin PTSD. There are fewer studies of noradrenergic function in the other anxiety disorders, and the findings there have not been consistent. These studies provide evidence for increased noradrenergic responsiveness in panic disorder and PTSD, although there does not appear to be an alteration in baseline noradrenergic function in these patients. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 06/04/20 alle ore 02:18:34