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Titolo:
MORPHOMETRIC STUDY OF THE GUBERNACULUM IN MALE ESTROGEN-RECEPTOR MUTANT MICE
Autore:
DONALDSON KM; TONG SYC; WASHBURN T; LUBAHN DB; EDDY EM; HUTSON JM; KORACH KS;
Indirizzi:
ROYAL CHILDRENS HOSP,FLEMINGTON RD PARKVILLE VIC 3052 AUSTRALIA ROYAL CHILDRENS HOSP,RES FDN,F DOUGLAS STEPHENS SURG RES LAB MELBOURNE VIC AUSTRALIA NIEHS,REPROD & DEV TOXICOL LAB,NIH RES TRIANGLE PK NC 27709
Titolo Testata:
Journal of andrology
fascicolo: 2, volume: 17, anno: 1996,
pagine: 91 - 95
SICI:
0196-3635(1996)17:2<91:MSOTGI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; HORMONAL-CONTROL; FETAL; CRYPTORCHIDISM; EXPRESSION;
Keywords:
ERKO; ESTROGEN; ESTROGEN RECEPTOR; CREMASTER; PROCESSUS VAGINALIS; TESTIS; GUBERNACULUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Donaldson et al., "MORPHOMETRIC STUDY OF THE GUBERNACULUM IN MALE ESTROGEN-RECEPTOR MUTANT MICE", Journal of andrology, 17(2), 1996, pp. 91-95

Abstract

To determine role of estrogen receptors in testicular descent, a morphometric study of the testis and structures derived from the gubernaculum was made in sexually mature male mice having an estrogen receptor disrupted gene mutation (ERKO). Macroscopic dissections and sagittal serial sections were made of the pelvis of four wild-type mice, four mice heterozygous for the ERKO mutation, and four homozygous ERKO males. By external morphological examination the testes appeared to be descended in all three genotypes. All mice had development of a cremaster sac, which is derived from the gubernaculum, but this was twice as large in wildtype mice than in both the heterozygote or homozygote ERKO groups. The cause for the smaller cremaster sac appeared to be excessivedevelopment of the cremaster muscle in ERKO mice. The thickened muscle was associated with postmortem retraction of the testes into the inguinal canal or abdomen. Spermatogenesis and testicular volume were deficient in homozygous ERKO mice at this age. This study demonstrates that estrogen has a previously unknown role in masculine sexual development of the gubernaculum and the structures derived from it, such as the cremaster muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:06:03