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Titolo:
DEVELOPMENTAL REMODELING OF THE INTERNAL ELASTIC LAMINA OF RABBIT ARTERIES - EFFECT OF BLOOD-FLOW
Autore:
WONG LCY; LANGILLE BL;
Indirizzi:
TORONTO GEN HOSP,TORONTO HOSP RES INST,CCRW 1 836,200 ELIZABETH ST TORONTO ON M5G 2C4 CANADA TORONTO GEN HOSP,TORONTO HOSP RES INST,CCRW 1 836 TORONTO ON M5G 2C4 CANADA UNIV TORONTO,ST MICHAELS HOSP,DEPT PATHOL TORONTO ON M5B 1W8 CANADA
Titolo Testata:
Circulation research
fascicolo: 5, volume: 78, anno: 1996,
pagine: 799 - 805
SICI:
0009-7330(1996)78:5<799:DROTIE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING MOUSE AORTA; SMOOTH-MUSCLE CELLS; CHEMICAL COMPOSITION; CAROTID ARTERIES; RAT AORTA; GROWTH; HYPERTENSION; ORGANIZATION; ENDOTHELIUM; JUNCTIONS;
Keywords:
ARTERIAL GROWTH; ELASTIN; SHEAR STRESS; FENESTRAE; ARTERIAL REMODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
L.C.Y. Wong e B.L. Langille, "DEVELOPMENTAL REMODELING OF THE INTERNAL ELASTIC LAMINA OF RABBIT ARTERIES - EFFECT OF BLOOD-FLOW", Circulation research, 78(5), 1996, pp. 799-805

Abstract

We examined remodeling of the internal elastic lamina (IEL) of rabbitarteries from 3 to 23 weeks of age. The IELs were fenestrated at all ages; however, the sizes of the fenestrae increased dramatically during postnatal development. Mean areas occupied by the individual fenestrae of the carotid artery IEL increased from 11.3+/-0.7 mu m(2) in 3-week-old rabbits to 61.2+/-5.5 mu m(2) in adult rabbits. The estimated number of fenestrae per vessel also increased greatly, from 2.68x10(5) to 9.27x10(5); however, the increased number of fenestrae did not keeppace with growth of the artery, since fenestrae per square millimeterdecreased by 26%. Large increases in the size of fenestrae were also observed in the renal and iliac arteries. although greater decreases in fenestrae per square millimeter occurred with age (70% in iliac arteries). Morphological assessments suggested that enlarging fenestrae frequently fuse with neighbors. By contrast with other arteries, the IELof the abdominal aorta was not a continuous fenestrated sheet in young animals, perhaps reflecting the extensive remodeling that this vessel undergoes in the postnatal period. We decreased common carotid bloodflow by 70% in 5 rabbits at 10 weeks of age by ligating the ipsilateral external carotid artery, and we approximately doubled blood how in 5 others at the same age, by contralateral common carotid ligation. At15 weeks of age, fenestrae in the artery carrying increased flow were39% larger than fenestrae in the control artery, whereas fenestrae a ere 53.5% smaller after 70% decreases in Bow (P<.05). We conclude thatflow-dependent enlargement of fenestrae contributes to developmental remodeling of the IEL. Remodeling of the IEL may also have important implications for transport of materials and cell-cell communication between the intima and media.

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Documento generato il 28/09/20 alle ore 03:58:58