Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RANDOMIZED STUDY OF N-OF-1 TRIALS VERSUS STANDARD PRACTICE
Autore:
MAHON J; LAUPACIS A; DONNER A; WOOD T;
Indirizzi:
UNIV WESTERN ONTARIO HOSP,ROOM 60F-11,POB 5339 LONDON ON N6A 5A5 CANADA UNIV WESTERN ONTARIO,DEPT MED & EPIDEMIOL LONDON ON CANADA UNIV WESTERN ONTARIO,DEPT BIOSTAT & EPIDEMIOL LONDON ON CANADA UNIV WESTERN ONTARIO,DEPT MED LONDON ON CANADA
Titolo Testata:
BMJ. British medical journal
fascicolo: 7038, volume: 312, anno: 1996,
pagine: 1069 - 1074
SICI:
0959-8138(1996)312:7038<1069:RSONTV>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; INDIVIDUAL PATIENTS; AMITRIPTYLINE; THEOPHYLLINE; EXPERIENCE; THERAPY; BENEFIT; DISEASE; QUALITY; LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J. Mahon et al., "RANDOMIZED STUDY OF N-OF-1 TRIALS VERSUS STANDARD PRACTICE", BMJ. British medical journal, 312(7038), 1996, pp. 1069-1074

Abstract

Objective-To compare outcomes between groups of patients with irreversible chronic airflow limitation given theophylline by n of 1 trials or standard practice. Design-Randomised controlled study of n of 1 trials versus standard practice. Setting-Tertiary care centre outpatient department. Subjects-31 patients with irreversible chronic airflow limitation who were unsure that theophylline was helpful after an open trial. Interventions-n Of 1 trials (single patient randomised multiple crossover comparisons of theophylline against placebo) followed published guidelines. For standard practice patients theophylline was stopped and resumed if their dyspnoea worsened; if their dyspnoea then improved theophylline was continued. For both groups a decision to continue or stop the drug was made within three months of randomisation. Main outcome measures-Exercise capacity as measured by six minute walking distance, quality of life as measured by the chronic respiratory disease questionnaire at baseline and six months after randomisation, and proportions of patients taking theophylline at six months. Results-26 patients completed follow up. 47% fewer n of 1 trial patients than standard practice patients were taking theophylline at six months (5/14 versus 10/12; 95% confidence interval of difference 14% to 80%) without differences in exercise capacity or quality of life. Conclusions-n Of 1 trials led to less theophylline use without adverse effects on exercisecapacity or quality of life in patients with irreversible chronic airflow limitation, These data directly support the presence of a clinically important bias towards unnecessary treatment during open prescription of theophylline for irreversible chronic airflow limitation. Confirmation in a larger study and similar studies for other problems appropriate for n of 1 trials are needed before widespread use of n of 1 trials can be advocated in routine clinical practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:52:21