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Titolo:
AUTORADIOGRAPHIC LOCALIZATION OF EXTRASTRIATAL D-2-DOPAMINE RECEPTORSIN THE HUMAN BRAIN USING [I-125] EPIDEPRIDE
Autore:
HALL H; FARDE L; HALLDIN C; HURD YL; PAULI S; SEDVALL G;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT CLIN NEUROSCI,PSYCHIAT SECT S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Synapse
fascicolo: 2, volume: 23, anno: 1996,
pagine: 115 - 123
SICI:
0887-4476(1996)23:2<115:ALOEDR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTORS; I-125 EPIDEPRIDE; PHARMACOLOGICAL CHARACTERIZATION; ANTIPSYCHOTIC AGENTS; SUBSTANTIA NIGRA; H-3 RACLOPRIDE; BASAL GANGLIA; D2 RECEPTORS; BINDING; SCHIZOPHRENIA;
Keywords:
D-2-DOPAMINE RECEPTOR; [I-125] EPIDEPRIDE; HUMAN BRAIN; WHOLE HEMISPHERE AUTORADIOGRAPHY; EXTRASTRIATAL REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
H. Hall et al., "AUTORADIOGRAPHIC LOCALIZATION OF EXTRASTRIATAL D-2-DOPAMINE RECEPTORSIN THE HUMAN BRAIN USING [I-125] EPIDEPRIDE", Synapse, 23(2), 1996, pp. 115-123

Abstract

Epidepride is a benzamide with high affinity for central D-2- and D-3- dopamine receptors. The anatomical distribution of [I-125]epidepridebinding was examined by autoradiography, using postmortem human whole-hemisphere cryosections. The density of [I-125]epidepride binding sites was high in caudate nucleus and putamen. [I-125]epidepride also labeled receptors in extrastriatal region such as in the pallidum, some thalamic nuclei, the neocortex, and the substantia nigra. The neocortical binding was heterogeneously distributed. In most cortical regions, binding sites were located in superficial layers (I-II). However, in basal levels of the occipital cortex, [I-125]epidepride binding was located in a deeper layer, probably corresponding to layer V. Competitionstudies indicated that most of the [I-125]epidepride binding represented predominantly D-2-dopamine receptors, in striatal as well as in extrastriatal regions. The presence of extrastriatal D-2-dopamine receptor populations is of particular interest for research on schizophreniaand antipsychotic drug action. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:28:20