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Titolo:
TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF EPIBATIDINE AFTER ACUTE AND CHRONIC ADMINISTRATION IN MICE
Autore:
DAMAJ MI; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,POB 980613 RICHMOND VA 23298
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 300, anno: 1996,
pagine: 51 - 57
SICI:
0014-2999(1996)300:1-2<51:TTTAEO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NICOTINE; PROLACTIN-RELEASE; BRAIN; RECEPTOR; RAT; DESENSITIZATION; CORTICOSTERONE; INJECTIONS; INFUSION; AGONIST;
Keywords:
NICOTINE; EPIBATIDINE; ANTINOCICEPTION; TOLERANCE; (MOUSE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj e B.R. Martin, "TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF EPIBATIDINE AFTER ACUTE AND CHRONIC ADMINISTRATION IN MICE", European journal of pharmacology, 300(1-2), 1996, pp. 51-57

Abstract

Epibatidine is a novel potent antinociceptive agent that acts throughnicotinic receptors. In this study we investigated the development oftolerance to the antinociceptive effects of epibatidine enantiomers after acute and chronic administration in mice using the tail-flick test. Contrary to nicotine, mice treated with epibatidine enantiomers at different times and doses did not develop significant tolerance after s.c. acute nor after repeated injections. In mice that chronically received (+)-epibatidine, no significant tolerance was seen after acute challenge with (+)-epibatidine. However, a significant shift in (-)-epibatidine's dose-response curve was obtained in animals that received (-)-epibatidine. In nicotine-tolerant animals, no significant tolerancewas seen after acute challenge with (+)-epibatidine. However, the animals were less sensitive to the acute (-)-epibatidine challenge. Our results show that development of tolerance to epibatidine antinociceptive effects has a different profile and characteristics than that foundfor nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:12:16