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Titolo:
INTERACTION OF ANGIOGENIC BASIC FIBROBLAST GROWTH-FACTOR WITH ENDOTHELIAL-CELL HEPARAN-SULFATE PROTEOGLYCANS - BIOLOGICAL IMPLICATIONS IN NEOVASCULARIZATION
Autore:
RUSNATI M; PRESTA M;
Indirizzi:
UNIV BRESCIA,SCH MED,DEPT BIOMED SCI & BIOTECHNOL,UNIT GEN PATHOL & IMMUNOL,VIA VALSABBINA 19 I-25123 BRESCIA ITALY UNIV BRESCIA,SCH MED,DEPT BIOMED SCI & BIOTECHNOL,UNIT GEN PATHOL & IMMUNOL I-25123 BRESCIA ITALY
Titolo Testata:
International journal of clinical & laboratory research
fascicolo: 1, volume: 26, anno: 1996,
pagine: 15 - 23
SICI:
0940-5437(1996)26:1<15:IOABFG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBENDOTHELIAL EXTRACELLULAR-MATRIX; PLASMINOGEN-ACTIVATOR PRODUCTION; PROTEOLYTIC DEGRADATION; 3-DIMENSIONAL STRUCTURE; RECEPTOR-BINDING; HIGH-AFFINITY; FACTOR BFGF; RELEASE; FGF; DIFFERENTIATION;
Keywords:
ANGIOGENESIS; ENDOTHELIUM; FIBROBLAST GROWTH FACTOR; HEPARIN; PROTEOGLYCANS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
M. Rusnati e M. Presta, "INTERACTION OF ANGIOGENIC BASIC FIBROBLAST GROWTH-FACTOR WITH ENDOTHELIAL-CELL HEPARAN-SULFATE PROTEOGLYCANS - BIOLOGICAL IMPLICATIONS IN NEOVASCULARIZATION", International journal of clinical & laboratory research, 26(1), 1996, pp. 15-23

Abstract

Basic fibroblast growth factor is an angiogenic molecule involved in several physiological and pathological processes, including wound repair, embryonic development; and tumor growth. In vitro, basic fibroblast growth factor induces an ''angiogenic phenotype'' in endothelial cells, which includes chemotaxis, mitogenesis, protease production, beta-integrin expression, and tube formation in three-dimensional gels. It acts by binding to specific tryosine kinase receptors and to cell-associated heparan sulfate proteoglycans. The physiological significance of the interaction with cell-associated and soluble heparan sulfate proteoglycans is manyfold. Heparan sulfate proteoglycans protect basic fibroblast growth factor from inactivation in the extracellular environment and modulate its bioavailability. At the cell surface, soluble andcell-associated heparan sulfate proteoglycans may play different roles in modulating the dimerization of the growth factor and its interaction with tyrosine kinase receptors. Finally, they affect the internalization and the intracellular fate of basic fibroblast growth factor, suggesting that growth factor slash proteoglycan complexes are involvedin intracellular delivery. The bioavailability and the biological activity of basic fibroblast growth factor on endothelial cells strictly depend on the glycosaminoglycan milieu of the extracellular environment. Hence the angiogenic activity of the growth factor in vivo might bemodulated by using exogenous glycosaminoglycans. The capacity of glycosaminoglycans to bind to and to influence the biological activity of basic fibroblast growth factor depends on size, degree of sulfation, and disaccharide composition, In the present paper we discuss the physiological significance and the biochemical bases of the interaction of the growth factor with heparan sulfate proteoglycans and exogenous glycosaminoglycans with a view to the possible therapeutic use of heparin-related oligosaccharides as basic fibroblast growth factor agonists or antagonists in angiogenesis-dependent diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:34:01