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Titolo:
GLYBURIDE ENHANCEMENT OF LACTATE PRODUCTION IN ISCHEMIC HEART IS MODIFIED BY PRECONDITIONING - AN IN-VIVO EXPERIMENTAL-STUDY IN PIGS BY MICRODIALYSIS TECHNIQUE
Autore:
WIKSTROM BG; RONQUIST G; WALDENSTROM A;
Indirizzi:
UMEA UNIV HOSP,DEPT CARDIOL S-90185 UMEA SWEDEN UMEA UNIV HOSP,DEPT CARDIOL S-90185 UMEA SWEDEN UMEA UNIV HOSP,DEPT CLIN CHEM S-90185 UMEA SWEDEN UNIV UMEA HOSP,DEPT CARDIOL UMEA SWEDEN
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 27, anno: 1996,
pagine: 622 - 628
SICI:
0160-2446(1996)27:5<622:GEOLPI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; RAT-HEART; MYOCARDIAL-ISCHEMIA; K+ CHANNELS; REPERFUSION; METABOLISM; OCCLUSION; RELEASE; DOGS;
Keywords:
HEART; GLYBURIDE; MICRODIALYSIS; ATP-DEPENDENT POTASSIUM CHANNEL; LACTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
B.G. Wikstrom et al., "GLYBURIDE ENHANCEMENT OF LACTATE PRODUCTION IN ISCHEMIC HEART IS MODIFIED BY PRECONDITIONING - AN IN-VIVO EXPERIMENTAL-STUDY IN PIGS BY MICRODIALYSIS TECHNIQUE", Journal of cardiovascular pharmacology, 27(5), 1996, pp. 622-628

Abstract

The concentrations of lactate, pyruvate, and adenosine, together withsome of their derivatives, were determined in microdialysates from 12pig hearts, 6 of which were subjected to preconditioning and 30 min of ischemia (index ischemia) and 6 of which were subjected to only 40 min of index ischemia. Two microdialysis probes were inserted in ischemic myocardium. Glyburide (10 mu M) in a modified isotonic Krebs-Ringerphosphate buffer was administered through one of the probes and plainisotonic phosphate buffer was administered through the other. Accordingly, the experimental setup permitted us to study the metabolic effects of glyburide on ischemic myocardium constituting two groups that were either preconditioned or unpreconditioned. The preconditioning effect was validated with area at risk and infarction area measurements in12 other pigs. We noted no functional differences between the groups. In I-he unpreconditioned group glyburide infusion re suited in enhanced similar to 60% lactate production during index ischemia. However, preconditioning attenuated the enhancing effect of glyburide on lactateproduction. The interplay between the effects of glyburide and preconditioning on ischemic myocardium is suggested to be dependent on the different modes of action on the K-ATP(+) channel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:28:22