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Titolo:
DUAL VASOACTIVE EFFECTS OF TOLAZOLINE ON RABBIT PULMONARY-ARTERIES
Autore:
LEE TS; HOU XH;
Indirizzi:
UNIV CALIF LOS ANGELES,HARBOR MED CTR,DEPT ANESTHESIOL,1000 W CARSON ST TORRANCE CA 90509
Titolo Testata:
Journal of cardiothoracic and vascular anesthesia
fascicolo: 3, volume: 10, anno: 1996,
pagine: 364 - 367
SICI:
1053-0770(1996)10:3<364:DVEOTO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL DIAPHRAGMATIC-HERNIA; HYPERTENSION; VASOSPASM; INFUSION; DOPAMINE; NEONATE; THERAPY; LAMBS;
Keywords:
TOLAZOLINE; PULMONARY VASOCONSTRICTOR; PULMONARY VASODILATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.S. Lee e X.H. Hou, "DUAL VASOACTIVE EFFECTS OF TOLAZOLINE ON RABBIT PULMONARY-ARTERIES", Journal of cardiothoracic and vascular anesthesia, 10(3), 1996, pp. 364-367

Abstract

Objectives: To determine the vasoactive effects of tolazoline on isolated rabbit pulmonary arteries. Design: Prospective, in vitro, randomized, controlled trial. Setting: Experimental laboratory in a university-affiliate hospital. Participants: New Zealand White Rabbits. Interventions: The pulmonary artery rings were obtained via thoracotomy. Their vasoactive responses were assessed in the presence and absence of intact endothelium and with or without precontraction by norepinephrine (NE, 3 x 10(-6) M) or potassium chloride (KCl, 3 x 10(-2) M). Using a tissue bath preparation, cumulative concentration response curves of tolazoline were obtained at different concentrations (10(-9) to 10(-4) M) after a period of stabilization. Measurements and Main Results: Tolazoline caused vasoconstriction of isolated pulmonary arteries withoutany pretreatment. The magnitude of the constriction was dose related and reached 300 g/g wet tissue at a concentration of 10(-4) M. On KCl-precontracted pulmonary arteries, tolazoline caused significant dose-related vasoconstriction. On the NE-precontracted vessel rings, it elicited significant dose-dependent vasodilation up to 60% relaxation at 10(-5) M. All the above effects were endothelium independent. Conclusions: Tolazoline has dual endothelium-independent vasoactive effects, causing vasoconstriction on isolated rabbit pulmonary arteries, either untreated or precontracted with KCI, and vasodilation on those precontracted with NE. Tolazoline may act as a competitive alpha-adrenoceptor blocking agent. Copyright (C) 1996 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:53:22