Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INDUCTION OF HOMOLOGOUS VIRUS NEUTRALIZING ANTIBODIES IN GUINEA-PIGS IMMUNIZED WITH 2 HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GLYCOPROTEIN GP120-ISCOM PREPARATIONS - A COMPARISON WITH OTHER ADJUVANT SYSTEMS
Autore:
SJOLANDER S; HANSEN JES; LOVGRENBENGTSSON K; AKERBLOM L; MOREIN B;
Indirizzi:
SWEDISH UNIV AGR SCI,COLL VET MED,DEPT VET MICROBIOL,SECT VIROL,BIOMEDICUM,BOX 585 S-75123 UPPSALA SWEDEN UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB,DEPT 144 DK-2650 HVIDOVRE DENMARK NATL VET INST,DEPT VIROL S-75123 UPPSALA SWEDEN
Titolo Testata:
Vaccine
fascicolo: 4, volume: 14, anno: 1996,
pagine: 344 - 352
SICI:
0264-410X(1996)14:4<344:IOHVNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONOCLONAL-ANTIBODIES; GP120 GLYCOPROTEIN; COMPLEXES ISCOMS; HIV-1; PROTEIN; INFECTION; RECEPTOR; CELLS; CHIMPANZEES; VACCINATION;
Keywords:
HIV-1; RECOMBINANT GP120; ISCOMS; VIRUS NEUTRALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Sjolander et al., "INDUCTION OF HOMOLOGOUS VIRUS NEUTRALIZING ANTIBODIES IN GUINEA-PIGS IMMUNIZED WITH 2 HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GLYCOPROTEIN GP120-ISCOM PREPARATIONS - A COMPARISON WITH OTHER ADJUVANT SYSTEMS", Vaccine, 14(4), 1996, pp. 344-352

Abstract

The immunogenicity in guinea-pigs of the human immunodeficiency virustype 1 envelope glycoprotein gp120 in immune stimulating complex (iscom) was compared to that of gp120 adjuvanted with QuilA-matrix (iscom without attached antigen), aluminium hydroxide (alum) and the Ribi adjuvant system. Gp120 was either incorporated into iscoms by covalent conjugation (iscom(c)) or by acid treatment of gp120 (iscom(a)) and boththese preparations induced high ELISA antibody titres to gp120. Virusneutralizing (VN) antibodies were most frequently induced by gp120 iniscom(c), iscom(a) or in alum and correlated to high titres to the V3-region of gp120. Further, antibodies induced by gp120-iscom(c) most efficiently inhibited binding of a VN monoclonal antibody GP13 to the CD4 binding region of gp120 whereas gp120-iscom(a) induced the highest mean titre of antibodies blocking the binding of [I-125]gp120 to CD4. These results suggest that the gp120-iscom preparations efficiently induced high levels of gp120 specific antibodies and that the adjuvant formulation of gp120 affect the specificity and functional properties of elicited antibodies. Copyright (C) 1996 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:21:55