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Titolo:
FLOW THRESHOLD FOR REDUCTION OF CYCLIC-AMP BINDING IN THE HIPPOCAMPUSCA(1) AND OTHER BRAIN-REGIONS DURING STROKE DEVELOPMENT IN GERBILS
Autore:
TANAKA K; GOMI S; MIHARA B; SHIRAI T; NOGAWA S; NOZAKI H; NAGATA E; KONDO T; FUKUUCHI Y;
Indirizzi:
KEIO UNIV,SCH MED,DEPT NEUROL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 3, volume: 16, anno: 1996,
pagine: 468 - 473
SICI:
0271-678X(1996)16:3<468:FTFROC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT-PROTEIN-KINASE; CEREBRAL BLOOD-FLOW; AUTORADIOGRAPHIC ANALYSIS; 2ND-MESSENGER SYSTEMS; MAMMALIAN BRAIN; ISCHEMIA; CORTEX; LOCALIZATION; RAT;
Keywords:
CEREBRAL ISCHEMIA; CYCLIC AMP; PROTEIN KINASE; 2ND MESSENGER; HIPPOCAMPUS; CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Tanaka et al., "FLOW THRESHOLD FOR REDUCTION OF CYCLIC-AMP BINDING IN THE HIPPOCAMPUSCA(1) AND OTHER BRAIN-REGIONS DURING STROKE DEVELOPMENT IN GERBILS", Journal of cerebral blood flow and metabolism, 16(3), 1996, pp. 468-473

Abstract

The flow threshold for alterations of the in vitro [H-3]cyclic AMP (cAMP) binding, an indicator of the total amount of particulate cAMP-dependent protein kinase, was evaluated in the gerbil brain after 30 min,2 h, and 6 h of unilateral common carotid artery occlusion, respectively. The autoradiographic method developed in our laboratory enabled us to measure the [H-3]cAMP binding and local CBF in each region of thesame brain. The ischemic flow thresholds for reduction of the cAMP binding in the hippocampus CA(1) were 18, 34, and 49 ml 100 g(-1) min(-1) after 30-min, 2-h, and 6-h ischemia, respectively. These values werehigher than those in other regions such as the hippocampus CA(3) and temporal cerebral cortex in each duration of ischemia. These findings indicate that (a) the ischemic flow threshold for perturbation of the cAMP system may be higher in the hippocampus CA(1) than in other brainregions, suggesting that the hippocampus CA(1) could be especially vulnerable to acute ischemic stress; and (b) the level of the aforementioned threshold may increase progressively during the time course of ischemia in particular regions such as the hippocampus CA(1) and CA(3), suggesting that the duration of ischemia exerts a definite influence on the viability of the ischemic neuronal cells in these regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:04:00