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Titolo:
HIGH-FREQUENCY OSCILLATIONS IN THE OUTPUT NETWORKS OF THE HIPPOCAMPAL-ENTORHINAL AXIS OF THE FREELY BEHAVING RAT
Autore:
CHROBAK JJ; BUZSAKI G;
Indirizzi:
RUTGERS STATE UNIV,CTR MOLEC & BEHAV NEUROSCI,197 UNIV AVE NEWARK NJ 07102 RUTGERS STATE UNIV,CTR MOLEC & BEHAV NEUROSCI NEWARK NJ 07102
Titolo Testata:
The Journal of neuroscience
fascicolo: 9, volume: 16, anno: 1996,
pagine: 3056 - 3066
SICI:
0270-6474(1996)16:9<3056:HOITON>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
THETA RHYTHM; SUBICULAR COMPLEX; MOVING RATS; CORTEX; MEMORY; BRAIN; CA1; NEURONS; INVITRO; CELLS;
Keywords:
HIPPOCAMPUS; SUBICULUM; ENTORHINAL CORTEX; OSCILLATIONS; SHARP WAVES; MEMORY; EPILEPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Chrobak e G. Buzsaki, "HIGH-FREQUENCY OSCILLATIONS IN THE OUTPUT NETWORKS OF THE HIPPOCAMPAL-ENTORHINAL AXIS OF THE FREELY BEHAVING RAT", The Journal of neuroscience, 16(9), 1996, pp. 3056-3066

Abstract

Population bursts of the CA3 network, which occur during eating, drinking, awake immobility, and slow-wave sleep, produce a large field excitatory postsynaptic potential throughout stratum radiatum of the CA1 field (sharp wave). The CA3 burst sets into motion a short-lived, dynamic interaction between CA1 pyramidal cells and interneurons, the product of which is a 200 Hz oscillatory field potential (ripple) and phase-related discharge of the CA1 network. Although many CA1 pyramidal neurons discharge during the time frame (50-100 msec) of each sharp wave, each wave of a ripple (similar to 5 msec) reflects the synchronization of more discrete subsets of CA1 neurons. When we used multi-site recordings in freely behaving rats, we observed ripples throughout the longitudinal extent (similar to 4-5 mm) of the dorsal CA1 region that were coherent for multiple cycles of each ripple. High-frequency ripples were also observed throughout the hippocampal-entorhinal output pathway that were concurrent but less coherent on a cycle-by-cycle basis. Single and multiunit neuronal activity was phase-related to local ripples throughout the hippocampal-entorhinal output pathway. Entorhinal ripples occurred 5-30 msec after the CA1 ripples and were related to the occurrence of an entorhinal sharp wave. Thus, during each hippocampal sharp wave, there is a powerful synchronization among the neuronal networks that connect the hippocampus to the neocortex. We suggest thatthis population interaction (1) biologically constrains theoretical models of hippocampal function and dysfunction and (2) has the capacityto support an ''off-line'' memory consolidation process.

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Documento generato il 26/01/20 alle ore 16:08:48