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Titolo:
DEGENERATION AND REGENERATION OF AXONS IN THE LESIONED SPINAL-CORD
Autore:
SCHWAB ME; BARTHOLDI D;
Indirizzi:
UNIV ZURICH,INST BRAIN RES,AUGUST FOREL STR 1 CH-8029 ZURICH SWITZERLAND
Titolo Testata:
Physiological reviews
fascicolo: 2, volume: 76, anno: 1996,
pagine: 319 - 370
SICI:
0031-9333(1996)76:2<319:DAROAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CELL-ADHESION MOLECULES; NEURITE GROWTH-INHIBITORS; DORSAL-ROOT GANGLION; CHONDROITIN SULFATE PROTEOGLYCAN; TRANSITORY TRAUMATIC PARAPLEGIA; MOUSE SCIATIC-NERVE; CNS WHITE MATTER; IMMUNOELECTRON MICROSCOPIC LOCALIZATION; DEVELOPMENTALLY-REGULATED EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
773
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Schwab e D. Bartholdi, "DEGENERATION AND REGENERATION OF AXONS IN THE LESIONED SPINAL-CORD", Physiological reviews, 76(2), 1996, pp. 319-370

Abstract

For many decades, the inability of lesioned central neurons to regrowwas accepted almost as a ''law of nature,'' and on the clinical level, spinal cord and brain lesions were seen as being irreversible. Todaywe are starting to understand the mechanisms of neuronal regenerationin the central nervous system and its presence in the periphery. There is now a rapid expansion in this field of neuroscience. Developmental neurobiology has produced tools and concepts that start to show their impact on regeneration research. This is particularly true for the availability of antibodies and factors and for the rapidly growing cellular and molecular understanding of crucial aspects of neurite growth,guidance, target finding, and synapse stabilization. New cell biological concepts on the mechanisms of neuron survival and death and on theinteraction of inflammatory cells with the central nervous system also find their way into the field of spinal cord and brain lesions and have, indeed, led already to new therapeutic approaches. This review briefly summarizes the current knowledge on the mechanisms involved in degeneration and tissue loss and in axonal regeneration subsequent to spinal cord lesions, particularly in mammals and humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:35:23