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Titolo:
PSYCHOLOGICAL EFFECTS OF A DRUG THAT FACILITATES BRAIN AMPA RECEPTORS
Autore:
LYNCH G; KESSLER M; ROGERS G; AMBROSINGERSON J; GRANGER R; SCHEHR RS;
Indirizzi:
UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92717 CORTEX PHARMACEUT INC IRVINE CA 92718
Titolo Testata:
International clinical psychopharmacology
fascicolo: 1, volume: 11, anno: 1996,
pagine: 13 - 19
SICI:
0268-1315(1996)11:1<13:PEOADT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
AMPA RECEPTOR MODULATOR; BDP-12; BLOOD PRESSURE; CX516; EWL TEST; HEART RATE; HUMAN SUBJECTS; PHARMACOKINETICS; TRIPLET MEMORY RECALL TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
G. Lynch et al., "PSYCHOLOGICAL EFFECTS OF A DRUG THAT FACILITATES BRAIN AMPA RECEPTORS", International clinical psychopharmacology, 11(1), 1996, pp. 13-19

Abstract

The effects of 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), a centrally active compound that facilitates AMPA receptor mediated synaptic responses, were tested in human subjects. Separate tests of delayed recall sere given prior to and nearly 3 h after administration of placebo (rt = 12) or drug (n = 36). Control subjects exhibited poorer performance in the second session than in the first while subjects given 600-1200 mg of the drug did not. There were no pre- vs post-treatment differences in immediate recall in either group. The drug did not reliably affect self-assessment scores for any of several psychological variables but did disrupt the normally present correlations for within-subject changes in the variables. These results suggest that AMPA receptormodulators may (1) improve memory under some circumstances and (2) produce psychological effects that are subtle or not related to specificmood states.

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Documento generato il 26/09/20 alle ore 11:18:29