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Titolo:
CLONIDINE ANTAGONIZES THE AVERSIVE EFFECTS OF OPIATE WITHDRAWAL AND THE REWARDING EFFECTS OF MORPHINE ONLY IN OPIATE WITHDRAWN RATS
Autore:
NADER K; VANDERKOOY D;
Indirizzi:
UNIV TORONTO,DEPT ANAT & CELL BIOL,NEUROBIOL RES GRP TORONTO ON M5S 1A8 CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 2, volume: 110, anno: 1996,
pagine: 389 - 400
SICI:
0735-7044(1996)110:2<389:CATAEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCES; LOCUS COERULEUS; PRECIPITATED WITHDRAWAL; RECEPTOR ANTAGONISTS; DEPENDENT RATS; BETA-ENDORPHIN; BRAIN; NALOXONE; STIMULATION; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
K. Nader e D. Vanderkooy, "CLONIDINE ANTAGONIZES THE AVERSIVE EFFECTS OF OPIATE WITHDRAWAL AND THE REWARDING EFFECTS OF MORPHINE ONLY IN OPIATE WITHDRAWN RATS", Behavioral neuroscience, 110(2), 1996, pp. 389-400

Abstract

The researchers asked whether clonidine, an alpha(2)-noradrenergic agonist, would block selectively the motivational effects of opiate withdrawal and whether clonidine's effects would respect the boundary between nondeprived and deprived motivational states. In a place conditioning paradigm, clonidine (0.05 mg/kg ip) blocked the rewarding effects of morphine in opiate-withdrawn rats (as well as the aversive properties of withdrawal itself), but did not affect morphine place preferences (2 and 20 mg/kg) in drug-naive rats. Furthermore, clonidine blocked the acquisition of morphine (15 mg/kg), but not LiCl (15 mg/kg), conditioned taste aversions in water-deprived rats. The results suggest that the motivational system activated in deprived animals includes dopaminergic and noradrenergic components that are in series with each other.

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Documento generato il 13/07/20 alle ore 11:08:01