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Titolo:
SERUM CORTICOSTERONE INCREASES REFLECT ENHANCED UPTAKE INHIBITOR-INDUCED ELEVATION OF EXTRACELLULAR 5-HYDROXYTRYPTAMINE IN RAT HYPOTHALAMUS
Autore:
FULLER RW; PERRY KW; HEMRICKLUECKE SK; ENGLEMAN E;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 1, volume: 48, anno: 1996,
pagine: 68 - 70
SICI:
0022-3573(1996)48:1<68:SCIREU>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; SEROTONIN UPTAKE; LILLY 110140; BRAIN-SEROTONIN; FLUOXETINE; MICRODIALYSIS; SECRETION; L-5-HYDROXYTRYPTOPHAN; PROLACTIN; DIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Fuller et al., "SERUM CORTICOSTERONE INCREASES REFLECT ENHANCED UPTAKE INHIBITOR-INDUCED ELEVATION OF EXTRACELLULAR 5-HYDROXYTRYPTAMINE IN RAT HYPOTHALAMUS", Journal of Pharmacy and Pharmacology, 48(1), 1996, pp. 68-70

Abstract

The increase in extracellular 5-hydroxytryptamine (5-HT) in rat hypothalamus following administration of fluoxetine, a 5-HT-uptake inhibitor, was enhanced by the injection of LY20613 [1-H-indol-4-yloxy]-3-[cyclohexylamino]-2-propanol maleate), a 5HT(1A) receptor antagonist, or by L-5-hydroxytryptophan (L-5-HTP), the 5-HT precursor. Elevation of serum corticosterone, measured as a functional output of hypothalamic 5-HT pathways, was greater in rats treated with fluoxetine plus LY206130or with fluoxetine plus L-5-HTP than in rats treated with the agents alone. Synergism between effects of fluoxetine and L-5HTP has often been reported, but this is the first report of an increased functional effect when a 5-HT1A receptor antagonist is combined with a 5-HT uptakeinhibitor to augment the increase in extracellular 5-HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:37:02