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Titolo:
CHROMOSOMAL LOCALIZATION OF THE MAMMALIAN PEPTIDE-METHIONINE SULFOXIDE REDUCTASE GENE AND ITS DIFFERENTIAL EXPRESSION IN VARIOUS TISSUES
Autore:
MOSKOVITZ J; JENKINS NA; GILBERT DJ; COPELAND NG; JURSKY F; WEISSBACH H; BROT N;
Indirizzi:
ROCHE INST MOLEC BIOL,ROCHE RES CTR NUTLEY NJ 07110 NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM FREDERICK MD 21702
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 8, volume: 93, anno: 1996,
pagine: 3205 - 3208
SICI:
0027-8424(1996)93:8<3205:CLOTMP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL-PIGMENT EPITHELIUM; ENZYMATIC REDUCTION; PROTEINS; RESIDUES; CLONING; DAMAGE; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J. Moskovitz et al., "CHROMOSOMAL LOCALIZATION OF THE MAMMALIAN PEPTIDE-METHIONINE SULFOXIDE REDUCTASE GENE AND ITS DIFFERENTIAL EXPRESSION IN VARIOUS TISSUES", Proceedings of the National Academy of Sciences of the United Statesof America, 93(8), 1996, pp. 3205-3208

Abstract

Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) is a ubiquitous protein that can reduce methionine sulfoxide residues in proteinsas well as in a large number of methyl sulfoxide compounds, The expression of MsrA in various rat tissues was determined by using immunocytochemical staining. Although the protein was found in all tissues examined, it,vas specifically localized to renal medulla and retinal pigmented epithelial cells, and it was prominent in neurons and throughout the nervous system. In addition, blood and alveolar macrophages showedhigh expression of the enzyme, The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chromosomes 13 and 8p21.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:03:21