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Titolo:
(-)-DELTA(9)-TETRAHYDROCANNABINOL ANTAGONIZES THE PERIPHERAL CANNABINOID RECEPTOR-MEDIATED INHIBITION OF ADENYLYL-CYCLASE
Autore:
BAYEWITCH M; RHEE RH; AVIDORREISS T; BREUER A; MECHOULAM R; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD IL-91120 JERUSALEM ISRAEL
Titolo Testata:
The Journal of biological chemistry
fascicolo: 17, volume: 271, anno: 1996,
pagine: 9902 - 9905
SICI:
0021-9258(1996)271:17<9902:(ATPC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS; TETRAHYDROCANNABINOL; ANANDAMIDE; MODULATION; INVITRO; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Bayewitch et al., "(-)-DELTA(9)-TETRAHYDROCANNABINOL ANTAGONIZES THE PERIPHERAL CANNABINOID RECEPTOR-MEDIATED INHIBITION OF ADENYLYL-CYCLASE", The Journal of biological chemistry, 271(17), 1996, pp. 9902-9905

Abstract

(-)-Delta(9)-Tetrahydrocannabinol ((-)-Delta(9)-THC) is the major active psychotropic component of the marijuana plant, Cannabis sativa. The membrane proteins that have been found to bind this material or its derivatives have been called the cannabinoid receptors. Two GTP-binding protein-coupled cannabinoid receptors have been cloned. CB1 or the neuronal cannabinoid receptor is found mostly in neuronal cells and tissues while CB2 or the peripheral cannabinoid receptor has been detected in spleen and in several cells of the immune system. It has previously been shown that activation of CB1 or CB2 receptors by cannabinoid agonists inhibits adenylyl cyclase activity. Utilizing Chinese hamster ovary cells and COS cells transfected with the cannabinoid receptors we report that (-)-Delta(9)-THC binds to both receptors with similar affinity. However, in contrast to its capacity to serve as an agonist for the CB1 receptor, (-)-Delta(9)-THC was only able to induce a very slight inhibition of adenylyl cyclase at the CB2 receptor. Morever, (-)-Delta(9)-THC antagonizes the agonist-induced inhibition of adenylyl cyclase mediated by CB2. Therefore, we conclude that (-)-Delta(9)-THC constitutes a weak antagonist for the CB2 receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:19:13