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Titolo:
NMDA RECEPTOR FUNCTION AND HUMAN COGNITION - THE EFFECTS OF KETAMINE IN HEALTHY-VOLUNTEERS
Autore:
MALHOTRA AK; PINALS DA; WEINGARTNER H; SIROCCO K; MISSAR CD; PICKAR D; BREIER A;
Indirizzi:
NATL INST MENTAL HLTH,EXPTL THERAPEUT BRANCH,9000 ROCKVILLE PIKE BLDG10,ROOM 4N212 BETHESDA MD 20892 NIAAA,DIV INTRAMURAL CLIN & BIOL RES BETHESDA MD 20892
Titolo Testata:
Neuropsychopharmacology
fascicolo: 5, volume: 14, anno: 1996,
pagine: 301 - 307
SICI:
0893-133X(1996)14:5<301:NRFAHC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; D-ASPARTATE RECEPTORS; SELECTIVE IMPAIRMENT; MEMORY; SCHIZOPHRENIA; PHENCYCLIDINE; ANTAGONISTS; ACQUISITION; BINDING; SYSTEM;
Keywords:
KETAMINE; COGNITION; MEMORY; PSYCHOTIC DISORDERS; RECEPTORS, N-METHYL-D-ASPARTATE, RECEPTORS, GLUTAMATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Malhotra et al., "NMDA RECEPTOR FUNCTION AND HUMAN COGNITION - THE EFFECTS OF KETAMINE IN HEALTHY-VOLUNTEERS", Neuropsychopharmacology, 14(5), 1996, pp. 301-307

Abstract

A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-aspartate (NMDA) receptor in memory and other cognitive processes. There is comparatively less information about this receptor system in human cognition. We examined the effects of subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, on two forms of memory, free recall and recognition, as well as attention and behavior in a double-blind, placebo-controlled, 1-hour infusion in 15 healthy volunteers. Ketamine produced decrements in free recall, recognition memory, and attention. In addition, ketamine induced a briefpsychosis in our healthy volunteers marked by thought disorder and withdrawal-retardation. Ketamine-induced memory impairments were not accounted for by changes in subject attention and were not significantly related to psychosis ratings. These data suggest that the NMDA receptor plays a direct role in two types of explicit memory. The implications of these data for the pathophysiology of schizophrenia are discussed.

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Documento generato il 02/04/20 alle ore 21:11:06