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Titolo:
BONE-MARROW BOOSTS FOLLOWING T-CELL-DEPLETED HAPLOIDENTICAL BONE-MARROW TRANSPLANTATION
Autore:
KLINE RM; STIEHM ER; COWAN MJ;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,DIV BONE MARROW TRANSPLANTAT SANFRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,DIV BONE MARROW TRANSPLANTAT SANFRANCISCO CA 94143 UNIV LOUISVILLE,DEPT PEDIAT,DIV HEMATOL ONCOL LOUISVILLE KY 40292 UNIV CALIF LOS ANGELES,DEPT PEDIAT,DIV IMMUNOL LOS ANGELES CA 90024
Titolo Testata:
Bone marrow transplantation
fascicolo: 4, volume: 17, anno: 1996,
pagine: 543 - 548
SICI:
0268-3369(1996)17:4<543:BBFTHB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; VERSUS-HOST DISEASE; SOYBEAN AGGLUTININ; LEUKEMIA; RECONSTITUTION; PREVENTION; ANTIBODY;
Keywords:
T-CELL DEPLETED; HAPLOIDENTICAL; BONE MARROW TRANSPLANTATION; SCID; 2ND TRANSPLANTS; BOOSTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kline et al., "BONE-MARROW BOOSTS FOLLOWING T-CELL-DEPLETED HAPLOIDENTICAL BONE-MARROW TRANSPLANTATION", Bone marrow transplantation, 17(4), 1996, pp. 543-548

Abstract

Nine patients transplanted for non-malignant conditions (eight severecombined immunodeficiency, one aplastic anemia) received lectin-treated T cell-depleted BMTs from haploidentical donors, Each patient subsequently received a second T cell-depleted transplant ('boost') from the same donor, without conditioning, because of a delay in the recoveryof T cell immunity associated with evidence of engraftment, The median time to boost after initial BMT was 0.5 years (range 0.2-4.6 years),No conditioning therapy was used prior to the boost (except one patient who received ATG) and no GVHD prophylaxis was used during either the initial or subsequent BMTs, Eight of the nine patients are survivingat a median follow-up of 2.9 years (range 0.3-6.2 years), Following BMT boost, T cell function improved with the lymphocyte proliferative responses to PHA, PWM and alloantigen all increasing at least eight-fold, The mean percentage of CD3(+) lymphocytes increased from 20 +/- 7% of total lymphocytes following the first BMT to 66 +/- 7% following the marrow boost (P < 0.001), This increase was generated primarily by an increase in the CD4(+) lymphocyte subset which increased from 13 +/-3% post-transplant to 44 +/- 6% after the BMT boost (P < 0.005), and was reflected in both the CD4(+)/Leu8(+) and CD4(+)/Leu8(-) lymphocytepopulations, Measurements of B cell immunity (immunoglobulins, isohemagglutinins and B cells) showed no significant effect of the marrow boosts, These results suggest that bone marrow 'boosts' are an effectivemeans for improving T cell immunity in patients who fail to recover adequate immune function after T cell-depleted bone marrow transplantation and may be applicable as immunotherapy following allogeneic BMT undertaken to treat malignancy.

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Documento generato il 11/07/20 alle ore 19:53:28