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Titolo:
PHARMACOLOGICAL PROFILE OF IOBITRIDOL, A NONIONIC IODINATED CONTRAST-MEDIUM
Autore:
IDEE JM; BALUT C; BEAUFILS H; BERTHOMMIER C; CAMBAR J; COROT C; DOUCET D; HARTL C; JAUDON MC; JACQUIAUD C; LAKHDAR B; POTIER M; SANTUS R; TROCHERIE S; VAUDON E; BONNEMAIN B;
Indirizzi:
LAB GUERBET,DIV RES & DEV,BP 50400 F-95943 AULNAY SOUS BOIS FRANCE GRP HOSP PITIE SALPETRIERE,BIOCHEM LAB PARIS FRANCE STATE ATOM ENERGY COMMISS,DEPT BIOL FONTENAY ROSES FRANCE NECKER ENFANTS MALAD HOSP,INSERM U423 PARIS FRANCE GRP RENAL PHYSIOL & PHYSIOPATHOL,FAC PHARM BORDEAUX FRANCE
Titolo Testata:
Acta radiologica
, volume: 37, anno: 1996, supplemento:, 400
pagine: 35 - 48
SICI:
0284-1851(1996)37:<35:PPOIAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR-FIBRILLATION; CORONARY ARTERIOGRAPHY; RAT-KIDNEY; OSMOLALITY; IOXAGLATE; IOHEXOL; IOPAMIDOL; VISCOSITY; RABBITS; SODIUM;
Keywords:
CONTRAST MEDIA, IOBITRIDOL; PHARMACOLOGY; CHEMOTOXICITY; EXPERIMENTAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Idee et al., "PHARMACOLOGICAL PROFILE OF IOBITRIDOL, A NONIONIC IODINATED CONTRAST-MEDIUM", Acta radiologica, 37, 1996, pp. 35-48

Abstract

The present article combines and summarizes the preclinic studies carried out in vitro and in vivo to determine the pharmacologic and biochemical profile of iobitridol, a new nonionic iodinated low-osmolality contrast medium (CM). The effects of this product on the main hemodynamic, bronchopulmonary, neurologic, renal, blood chemistry and electrophysiologic parameters and RBC morphology were studied in detail in comparison with CM in the same chemical category or with reference substances of the same osmolality. The in vivo studies were performed under conditions resembling clinical use. Iobitridol showed an excellent pharmacologic and biochemical profile, which was identical or superior tothat of other products in its category.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 16:56:13