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Titolo:
PHARMACOKINETIC PROFILE OF IOBITRIDOL
Autore:
DENCAUSSE A; VIOLAS X; FELDMAN H; HAVARD P; CHAMBON C;
Indirizzi:
LAB GUERBET,RES CTR,BP 50400 F-95943 ROISSY FRANCE
Titolo Testata:
Acta radiologica
, volume: 37, anno: 1996, supplemento:, 400
pagine: 25 - 34
SICI:
0284-1851(1996)37:<25:PPOI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
CONTRAST MEDIA, IOBITRIDOL; PHARMACOKINETICS; PHYSICOCHEMICAL FEATURES; EXPERIMENTAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Dencausse et al., "PHARMACOKINETIC PROFILE OF IOBITRIDOL", Acta radiologica, 37, 1996, pp. 25-34

Abstract

Iobitridol (Xenetix) is a new triiodinated monomer, nonionic, low-osmolality contrast agent. Animal pharmacokinetic studies (rats, rabbits,dogs) and in vitro studies show that it is a marker of extracellular fluid, i.e. it is distributed in the interstitial space, it does not penetrate into cells, it does not cross the healthy blood-brain barrier(BBB), it does not bind to proteins, and it is eliminated by glomerular filtration without secretion or reabsorption. These characteristicsdetermine its use as an urography and angiography contrast agent as well as the precautions necessary to be taken, which are classical for contrast agents of this classification, related to administration in pathophysiologic populations (patients with renal failure, pregnant women or nursing mothers, neonates, etc.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:26:44