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Titolo:
TOXICOLOGIC PROFILE OF IOBITRIDOL, A NEW NONIONIC LOW-OSMOLALITY CONTRAST-MEDIUM
Autore:
DONADIEU AM; IDEE JM; DOUCET D; LEGROS A; PENATI S; NAINDITDUCRET M; MARMION F; BONNEMAIN B;
Indirizzi:
LAB GUERBET,RES CTR,BP 50400 F-95943 ROISSY FRANCE LAB GUERBET,RES CTR AULNAY SOUS BOIS FRANCE
Titolo Testata:
Acta radiologica
, volume: 37, anno: 1996, supplemento:, 400
pagine: 17 - 24
SICI:
0284-1851(1996)37:<17:TPOIAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE RENAL-FAILURE; RAT; CARCINOGENS; MUTAGENS; AGENTS;
Keywords:
CONTRAST MEDIA, IOBITRIDOL; TOXICOLOGY; EXPERIMENTAL STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Donadieu et al., "TOXICOLOGIC PROFILE OF IOBITRIDOL, A NEW NONIONIC LOW-OSMOLALITY CONTRAST-MEDIUM", Acta radiologica, 37, 1996, pp. 17-24

Abstract

Purpose: The toxicologic profile of iobitridol, a new nonionic low-osmolality contrast medium, was evaluated in compliance with the currentregulatory requirements in Europe, the USA and Canada. Material and Methods: The toxicity of iobitridol was tested following acute or repeated i.v. administration in several different species (mouse, rat, dog); single oral administration in the mouse and intracisternal injectionin the rat. Furthermore, teratogenicity and mutagenicity were evaluated in the rat and rabbit. Local perivenous toxicity was assessed in the rabbit. Results: The acute toxicity of iobitridol in the mouse is equivalent to that of iohexol, a reference product tested under the sameconditions. Chronic administration (daily i.v. injection over 4 weeks) in the rat and dog did not demonstrate any particular toxicity for iobitridol. It should be noted that, unlike iohexol, iobitridol did notprovoke any vacuolization of the renal tubular cells in the rat following repeated injections, Furthermore, this contrast agent did not show any teratogenic or mutagenic potential. The typical local inflammatory signs observed following perivenous injection in the rabbit were low in intensity and reversible. Conclusion: The toxicologic profile of iobitridol appears to be favorable and does not show any particular risk for clinical use under the usual indications of water-soluble iodinated contrast agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 16:22:53