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Titolo:
CEREBRAL AMYLOID-BETA PROTEIN DEPOSITS AND OTHER ALZHEIMER LESIONS INNONDEMENTED ELDERLY EAST AFRICANS
Autore:
OGENGO JA; COHEN DL; SAYI JG; MATUJA WB; CHANDE HM; KITINYA JN; KIMANI JK; FRIEDLAND RP; MORI H; KALARIA RN;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT NEUROL BRB5,10900 EUCLID AVE CLEVELANDOH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROL BRB5 CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PATHOL CLEVELAND OH 44106 UNIV NAIROBI,DEPT HUMAN ANAT NAIROBI KENYA MUHIMBILI MED CTR,NEUROL UNIT DAR ES SALAAM TANZANIA MUHIMBILI MED CTR,INST PATHOL DAR ES SALAAM TANZANIA TOKYO INST PSYCHIAT,SETAGAYA KU TOKYO 156 JAPAN
Titolo Testata:
Brain pathology
fascicolo: 2, volume: 6, anno: 1996,
pagine: 101 - 107
SICI:
1015-6305(1996)6:2<101:CAPDAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURITIC PLAQUES; DISEASE; EPIDEMIOLOGY; TANGLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Ogengo et al., "CEREBRAL AMYLOID-BETA PROTEIN DEPOSITS AND OTHER ALZHEIMER LESIONS INNONDEMENTED ELDERLY EAST AFRICANS", Brain pathology, 6(2), 1996, pp. 101-107

Abstract

There is little knowledge of the existence of Alzheimer disease (AD) or Alzheimer type of dementia in indigenous populations of developing countries;. In an effort to evaluate this, we assessed the deposition of amyloid beta (A beta) protein and other lesions associated with AD in brains of elderly East Africans. Brain tissues were examined from 32 subjects, aged 45 to 83 years with no apparent neurological disease,who came to autopsy at two medical Institutions in Nairobi and Dar esSalaam. An age-matched sample from subjects who had died from similarcauses in Cleveland was assessed in parallel. Of the 20 samples from Nairobi, 3 (15%) brains exhibited neocortical A beta deposits that varied from numerous diffuse to highly localized compact or neuritic plaques, many of which were also thioflavin S positive. Two of the cases had profound AR deposition in the prefrontal and temporal cortices and one of these also exhibited moderate to severe cerebral amyloid angiopathy. Similarly, 2 of the 12 samples from Dar es Salaam exhibited diffuse and compact A beta deposits that were also predominantly reactive for the longer A beta(42) species compared to A beta(40) We also notedthat A beta plaques were variably immunoreactive for amyloid associated proteins, apolipoprotein E, serum amyloid P and complement C3. Tau protein reactive neurofibrillary tangles (NFT) were also evident in the hippocampus of 4 subjects. By comparison, 4 (20%) of the 20 samples from randomly selected autopsies performed in Cleveland showed A beta deposits within diffuse and compact parenchymal plaques and the vasculature. These observations suggest A beta deposition and some NFT in brains of non-demented East Africans are qualitatively and quantitatively similar to that in age-matched elderly controls from Cleveland. While our small scale study does not document similar prevalence rates of preclinical AD, it suggests that elderly East Africans are unlikely toescape AD as it is known in developed countries.

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Documento generato il 27/11/20 alle ore 07:29:28