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Titolo:
SFA-1, A NOVEL CELLULAR GENE INDUCED BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1, IS A MEMBER OF THE TRANSMEMBRANE-4 SUPERFAMILY
Autore:
HASEGAWA H; UTSUNOMIYA Y; KISHIMOTO K; YANAGISAWA K; FUJITA S;
Indirizzi:
EHIME UNIV,SCH MED,DEPT INTERNAL MED 1 SHIGENOBU EHIME 79102 JAPAN
Titolo Testata:
Journal of virology
fascicolo: 5, volume: 70, anno: 1996,
pagine: 3258 - 3263
SICI:
0022-538X(1996)70:5<3258:SANCGI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-ASSOCIATED ANTIGEN; MONOCLONAL-ANTIBODIES; MOLECULAR-CLONING; SYNCYTIUM FORMATION; MRC OX-44; HTLV-I; MEMBRANE-PROTEIN; SURFACE PROTEINS; HUMAN MONOCYTES; C33 ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
H. Hasegawa et al., "SFA-1, A NOVEL CELLULAR GENE INDUCED BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1, IS A MEMBER OF THE TRANSMEMBRANE-4 SUPERFAMILY", Journal of virology, 70(5), 1996, pp. 3258-3263

Abstract

A novel cellular gene termed SFA-1 was isolated by differential hybridization of a cDNA library, using probes obtained from an adult T-cellleukemia cell line in comparison with probes obtained from normal CD4(+) T cells and the MOLT-4 cell line. The mRNA of the SFA-1 gene is approximately 1.6 kb in size and encodes a protein of 253 amino acids, containing four putative transmembrane domains, a number of cysteine residues, and one potential N-glycosylation site in a major hydrophilic region between the third and fourth transmembrane domains. Expression of the SFA-1 gene was either absent or present at a low level in lymphoid cells but was up-regulated after transformation by human T-cell leukemia virus type 1 and transactivated by Tax. SFA-1 was broadly expressed in many human cell types and conserved in different species. Computer-aided comparison showed that SFA-1 had significant sequence homology and common structural features with members of the transmembrane 4superfamily. SFA-1 antigen was detected as a 29-kDa membrane protein by immunoblotting, using anti-SFA-1 monoclonal antibody.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:27:46