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Titolo:
THE EFFECT OF THE APOLIPOPROTEIN-E PHENOTYPE ON PLASMA-LIPIDS IS NOT INFLUENCED BY ENVIRONMENTAL VARIABILITY - RESULTS OF A DUTCH TWIN STUDY
Autore:
DEKNIJFF P; BOOMSMA DI; DEWIT E; KEMPEN HJM; LEUVEN JAG; FRANTS RR; HAVEKES LM;
Indirizzi:
TNO,IVVO,GAUBIUS LAB,POB 430 2300 AK LEIDEN NETHERLANDS TNO,IVVO,GAUBIUS LAB,POB 430 2300 AK LEIDEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT PSYCHON 1007 MC AMSTERDAM NETHERLANDS F HOFFMANN LA ROCHE & CO LTD,DEPT PRPV CH-4002 BASEL SWITZERLAND LEIDEN UNIV,DEPT HUMAN GENET 2300 RA LEIDEN NETHERLANDS
Titolo Testata:
Human genetics
fascicolo: 3, volume: 91, anno: 1993,
pagine: 268 - 272
SICI:
0340-6717(1993)91:3<268:TEOTAP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DENSITY-LIPOPROTEIN RECEPTOR; E POLYMORPHISM; SERUM-CHOLESTEROL; GENETIC-VARIATION; RISK-FACTORS; E-APOPROTEIN; METABOLISM; INTERVENTION; CLEARANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
P. Deknijff et al., "THE EFFECT OF THE APOLIPOPROTEIN-E PHENOTYPE ON PLASMA-LIPIDS IS NOT INFLUENCED BY ENVIRONMENTAL VARIABILITY - RESULTS OF A DUTCH TWIN STUDY", Human genetics, 91(3), 1993, pp. 268-272

Abstract

We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE inmonozygotic (MZ) twins, and estimated whether or not there was a interaction between the apoE polymorphism and environmental factors. In 65MZ twin pairs, the intrapair differences in the measured lipoprotein parameters were similar in the different apoE phenotype classes. This indicates that the effect of the apoE polymorphism is not influenced by environmental variability between the MZ pair members and accordingly identifies the APOE gene as a ''level'' gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:48:37