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Titolo:
LOSARTAN (DUP-753) BLOCKS THE NATRIURETIC, KALIURETIC AND ANTIDIURETIC EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF CARBACHOL IN WATER-LOADED RATS
Autore:
SAAD WA; LUIZ AC; CAMARGO LAA; RENZI A; MENANI JV; SAAD WA;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA,1680,CAIXA POSTAL 331 BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 4, volume: 29, anno: 1996,
pagine: 511 - 513
SICI:
0100-879X(1996)29:4<511:L(BTNK>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
II RECEPTOR SUBTYPES; AREA;
Keywords:
AT1 RECEPTORS; CARBACHOL; ELECTROLYTE BALANCE; LOSARTAN; DUP-753; ANGIOTENSIN II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "LOSARTAN (DUP-753) BLOCKS THE NATRIURETIC, KALIURETIC AND ANTIDIURETIC EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF CARBACHOL IN WATER-LOADED RATS", Brazilian journal of medical and biological research, 29(4), 1996, pp. 511-513

Abstract

We determined the effect of intracerebroventricular (icv) administration of losartan, an angiotensin II (ANG II) subtype 1 receptor (AT1) antagonist, on icv carbachol-induced natriuresis, kaliuresis and antidiuresis in water-loaded male Holtzman rats (250-300 g) with a cannula implanted into the lateral ventricle (LV). The rats were water loaded with 5% of their body weight by gavage twice, with the second gavage one hour after the first. Carbachol (2 nmol in 1 mu l) was injected icv immediately after the second load. When losartan (DUP-753, 50 nmol in 1 mu l) was administered icv, it was given 3 min before carbachol. Previous icv treatment with losartan significantly reduced the icv carbachol-induced natriuresis (324 +/- 17 mu Eq/120 min), kaliuresis (103 +/- 15 mu Eq/120 min) and antidiuresis (13.5 +/- 2.1 ml/120 min) compared to the effects of previous icv injection of saline (Nai excretion = 498 +/- 22 mu Eq/120 min; K+ excretion = 167 +/- 20 mu Eq/120 min; urine volume = 5.2 +/- 1.2 ml/120 min). These results, reported as means /- SEM for 12 rats in each group, are consistent with the hypothesis that AT1 subtype receptors participate in the regulation of body electrolyte balance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:48:37