Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITORY EFFECT OF DUP-753 ON THE DRINKING RESPONSES OF RATS TO CENTRAL ADMINISTRATION OF NORADRENALINE AND ANGIOTENSIN-II AND TO DEHYDRATION
Autore:
REIS LC; SAAD WA; CAMARGO LAA; MENANI JV; SILVEIRA JEN; SAAD WA;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA,1680,CAIXA POSTAL 331 BR-14801903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 4, volume: 29, anno: 1996,
pagine: 507 - 510
SICI:
0100-879X(1996)29:4<507:IEODOT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONISTS; BINDING-SITES; ALPHA-2-ADRENOCEPTORS; BRAIN; ALPHA-1-ADRENOCEPTORS; HYPOTHALAMUS; SUBTYPES;
Keywords:
DUP-753; WATER INTAKE; ANGIOTENSIN; NORADRENALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L.C. Reis et al., "INHIBITORY EFFECT OF DUP-753 ON THE DRINKING RESPONSES OF RATS TO CENTRAL ADMINISTRATION OF NORADRENALINE AND ANGIOTENSIN-II AND TO DEHYDRATION", Brazilian journal of medical and biological research, 29(4), 1996, pp. 507-510

Abstract

We investigated the effect of losartan (DUP-753) on the dipsogenic responses produced by intracerebroventricular (icv) injection of noradrenaline (40 nmol/mu l) and angiotensin II (ANG II) (2 ng/mu l) in male Holtzman rats weighing 250-300 g. The effect of DUP-753 was also studied in animals submitted to water deprivation for 30 h. After control injections of isotonic saline (0.15 M NaCl, 1 mu l) into the lateral ventricle (LV) the water intake was 0.2 +/- 0.01 ml/h. DUP-753 (50 nmol/mu l) when injected alone into the LV of satiated animals had no significant effect on drinking (0.4 +/- 0.02 ml/h) (N = 8). DUP-753 (50 nmol/mu l) injected into the LV prior to noradrenaline reduced the water intake from 2.4 +/- 0.8 to 0.8 +/- 0.2 ml/h (N = 8). The water intake induced by injection of ANG II and water deprivation was also reduced from 9.2 +/- 1.4 and 12.7 +/- 1.4 ml/h to 0.8 +/- 0.2 and 1.7 +/- 0.3 ml/h (N = 6 and N = 8), respectively. These data indicate a correlation between noradrenergic pathways and angiotensinergic receptors and lead us to conclude that noradrenaline-induced water intake may be due to the release of ANG II by the brain. The finding that water intake was reduced by DUP-753 in water-deprived animals suggests that dehydration releases ANG II, and that AT(1) receptors of the brain play an important role in the regulation of water intake induced by deprivation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:23:01