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Titolo:
EFFECT OF AMINOGUANIDINE ON THE FREQUENCY OF NEUROAXONAL DYSTROPHY INTHE SUPERIOR MESENTERIC SYMPATHETIC AUTONOMIC GANGLIA OF RATS WITH STREPTOZOCIN-INDUCED DIABETES
Autore:
SCHMIDT RE; DORSEY DA; BEAUDET LN; REISER KM; WILLIAMSON JR; TILTON RG;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DIV ANAT PATHOL ST LOUIS MO 63110 UNIV TEXAS,HOUSTON HLTH SCI CTR,DEPT LAB MED & PATHOL HOUSTON TX 00000 UNIV CALIF DAVIS,SCH MED,DEPT MED DAVIS CA 95616
Titolo Testata:
Diabetes
fascicolo: 3, volume: 45, anno: 1996,
pagine: 284 - 290
SICI:
0012-1797(1996)45:3<284:EOAOTF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; NITRIC-OXIDE SYNTHASE; PERIPHERAL-NERVE; VASCULAR DYSFUNCTION; NEUROPATHY; GLYCOSYLATION; MELLITUS; PROTEIN; COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Schmidt et al., "EFFECT OF AMINOGUANIDINE ON THE FREQUENCY OF NEUROAXONAL DYSTROPHY INTHE SUPERIOR MESENTERIC SYMPATHETIC AUTONOMIC GANGLIA OF RATS WITH STREPTOZOCIN-INDUCED DIABETES", Diabetes, 45(3), 1996, pp. 284-290

Abstract

Aminoguanidine, which prevents formation of advanced glycation end products and is a relatively selective potent inhibitor of the inducible(versus constitutive) isoform(s) of nitric oxide synthase, has been reported to ameliorate structural and functional abnormalities in peripheral somatic nerves in rats with streptozocin (STZ)-induced diabetes. In the present studies, the effects of aminoguanidine treatment on ultrastructural changes in the autonomic nervous system of rats with STZ-induced diabetes were examined. The frequency of neuroaxonal dystrophy, the neuropathological hallmark of sympathetic autonomic neuropathy in diabetic rats, increased 9- to 11-fold in the superior mesenteric ganglia of 7- and 10-month STZ-diabetic rats compared with that in age-matched controls. Administration of aminoguanidine continuously from the time of induction of diabetes at a dose equal to or in excess of that providing a salutary effect in the diabetic somatic peripheral nervous system did not alter the severity of diabetes as assessed by plasma glucose level, 24-h urine volume, and levels of glycated hemoglobin. Chronic aminoguanidine therapy did not diminish the frequency or affect the ultrastructural appearance of neuroaxonal dystrophy in diabeticor age-matched control rat sympathetic ganglia after 7 or, 10 months of continuous administration. Our findings (under these experimental conditions) do not support a role for, aminoguanidine-sensitive processes in the development of sympathetic neuroaxonal dystrophy in diabeticrats. Glycation-linked aminoguanidine-insensitive processes, however,such as the formation of early glucose adducts (Schiff bases and Amadori products) with intracellular and/or extracellular proteins and amine-containing lipids, superoxide anion generation during subsequent autoxidation of these glucose adducts, and non-glycative processes, remain potential pathogenetic mechanisms for diabetic autonomic neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:58:54