Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVALUATION OF EXOGENOUS SURFACTANT TREATMENT STRATEGIES IN AN ADULT MODEL OF ACUTE LUNG INJURY
Autore:
LEWIS JF; GOFFIN J; YUE P; MCCAIG LA; BJARNESON D; VELDHUIZEN RAW;
Indirizzi:
UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED,268GROSVENOR ST LONDON ON N6A 4V2 CANADA
Titolo Testata:
Journal of applied physiology
fascicolo: 4, volume: 80, anno: 1996,
pagine: 1156 - 1164
SICI:
8750-7587(1996)80:4<1156:EOESTS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; PULMONARY SURFACTANT; CHEMICAL-COMPOSITION; SENSITIVE METHOD; REPLACEMENT; METABOLISM;
Keywords:
EXOGENOUS SURFACTANT THERAPY; ACUTE RESPIRATORY DISTRESS SYNDROME; PULMONARY SURFACTANT DISTRIBUTION; SURVANTA; BOVINE LIPID EXTRACT SURFACTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Lewis et al., "EVALUATION OF EXOGENOUS SURFACTANT TREATMENT STRATEGIES IN AN ADULT MODEL OF ACUTE LUNG INJURY", Journal of applied physiology, 80(4), 1996, pp. 1156-1164

Abstract

Two exogenous surfactant preparations [Survanta and bovine lipid extract surfactant (BLES)] were evaluated in saline lavage-injured adult sheep with two different delivery methods (instillation vs. aerosolization). Instilled BLES resulted in the greatest improvement in lung function, followed by aerosolized Survanta and then instilled Survanta. Aerosolized BLES was ineffective. Total surfactant recovery and distribution patterns were similar for Survanta and BLES for each delivery method tested. There were significant differences, however in the proportion of surfactant recovered in the alveolar wash relative to the lung tissue between the groups at killing. Moreover, the ratio of poorly functioning small surfactant aggregates to superior functioning large aggregates isolated from alveolar wash samples correlated with the physiological responses. The calculated contribution of secreted endogenoussurfactant to the total alveolar phospholipid pool at killing was significantly greater for the aerosolized Survanta group compared with the aerosolized BLES group. This finding suggested that there were differences in the interaction of the exogenous surfactants and their alveolar environments. We conclude that the response to exogenous surfactant in acute lung injury depends not only on the preparation used but also on how the surfactants are delivered to the injured lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 03:34:21