Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELECTIVE INTESTINAL DECONTAMINATION WITH NORFLOXACIN REDUCES BACTERIAL TRANSLOCATION IN ASCITIC CIRRHOTIC RATS EXPOSED TO HEMORRHAGIC-SHOCK
Autore:
LLOVET JM; BARTOLI R; PLANAS R; VINADO B; PEREZ J; CABRE E; ARNAL J; OJANGUREN I; AUSINA V; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET E-08916 BADALONA CATALUNYA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL E-08916 BADALONA CATALUNYA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT MICROBIOL BADALONA CATALUNYA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT PATHOL,RES UNIT BADALONA CATALUNYA SPAIN
Titolo Testata:
Hepatology
fascicolo: 4, volume: 23, anno: 1996,
pagine: 781 - 787
SICI:
0270-9139(1996)23:4<781:SIDWNR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL HEMORRHAGE; ALCOHOLIC CIRRHOSIS; PERITONITIS; INFECTION; MODEL; GUT; PROGNOSIS; TRACT; FLORA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Llovet et al., "SELECTIVE INTESTINAL DECONTAMINATION WITH NORFLOXACIN REDUCES BACTERIAL TRANSLOCATION IN ASCITIC CIRRHOTIC RATS EXPOSED TO HEMORRHAGIC-SHOCK", Hepatology, 23(4), 1996, pp. 781-787

Abstract

Bacterial translocation (BT) can be involved in the pathogenesis of severe infections due to bacteria of enteric origin that complicates bleeding cirrhotic patients, To assess the effect of hemorrhagic shock (HS) on the incidence of BT and if selective intestinal decontamination(SID) reduces this incidence, we studied six groups of Sprague-Dawleyrats: ascitic rats, ascitic rats exposed to IIS with and without previous norfloxacin prophylaxis, healthy rats, and healthy shocked rats with and without previous norfloxacin prophylaxis. BT tended to be higher in ascitic rats with shock than without shock (69% vs. 41%, P =.15)and was significantly higher in healthy rats with than without shock (50% vs. 0%, P =.01). Norfloxacin significantly reduced translocation in ascitic shocked rats in comparison with nondecontaminated ascitic shocked rats (31% vs. 69%, P =.038). This effect was due mainly to a reduction of gram-negative BT (0% vs. 37%, P =.008), In addition, norfloxacin prevented translocation in healthy shocked rats. Accordingly, aerobic gram-negative bacteria disappeared from fecal flora in all rats administered norfloxacin, except for Klebsiella species in one controlrat. Cecal severe submucosal edema, chronic inflammatory infiltrate, and intestinal lymphangiectasia were significantly more frequent in ascitic rats than in control rats, Intestinal mucosal injury related with HS, particularly subepithelial cecal edema, was observed only in ascitic shocked rats, In conclusion, HS increases the incidence of BT both in ascitic cirrhotic and healthy rats, Norfloxacin reduces significantly the incidence of translocation after shock, especially in those cases caused by aerobic gram-negative bacilli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:13:10