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Titolo:
DETECTION OF JC VIRUS-DNA IN THE PERIPHERAL-BLOOD LEUKOCYTES OF HIV-INFECTED PATIENTS
Autore:
DUBOIS V; LAFON ME; RAGNAUD JM; PELLEGRIN JL; DAMASIO F; BAUDOUIN C; MICHAUD V; FLEURY HJA;
Indirizzi:
UNIV BORDEAUX 2,VIROL LAB,146 RUE LEO SAIGNAT F-33076 BORDEAUX FRANCE UNIV BORDEAUX 2,PELLEGRIN HOSP,DEPT VIROL F-33076 BORDEAUX FRANCE UNIV BORDEAUX 2,PELLEGRIN HOSP,DEPT INFECT DIS F-33076 BORDEAUX FRANCE UNIV BORDEAUX 2,HAUT LEVEQUE HOSP,DEPT INFECT DIS F-33076 BORDEAUX FRANCE UNIV BORDEAUX 2,HAUT LEVEQUE HOSP,DEPT VIROL F-33076 BORDEAUX FRANCE
Titolo Testata:
AIDS
fascicolo: 4, volume: 10, anno: 1996,
pagine: 353 - 358
SICI:
0269-9370(1996)10:4<353:DOJVIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; POLYMERASE CHAIN-REACTION; BRAIN-TISSUE; CEREBROSPINAL-FLUID; BK-VIRUS; AIDS PATIENTS; AMPLIFICATION; HYBRIDIZATION; PATHOGENESIS; SEQUENCES;
Keywords:
VIRUS; HIV-1; AIDS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; LEUKOCYTES; GENE AMPLIFICATION; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
V. Dubois et al., "DETECTION OF JC VIRUS-DNA IN THE PERIPHERAL-BLOOD LEUKOCYTES OF HIV-INFECTED PATIENTS", AIDS, 10(4), 1996, pp. 353-358

Abstract

Objectives: To assess whether JC virus (JCV) DNA is frequently harboured by peripheral blood leukocytes (PBL) in HIV-positive patients, before the onset of progressive multifocal leukoencephalopathy (PML). Design: The polyomavirus JCV induces PML in immunocompromised persons andparticularly AIDS patients. Leukocytes may play a central part in theonset of PML, but their precise role in JCV latency and reactivation still remains hypothetical. The controversial presence of JCV DNA in PBL has been, until now, investigated only among small groups of patients. We therefore studied 157 HIV-positive persons and compared them with 65 HIV-negative immunocompromised patients. Methods: DNA was extracted from PBL. The presence of!CV DNA was demonstrated by the polymerase chain reaction (PCR) alone or combined with a molecular hybridization assay. Results: The presence of JCV DNA was ascertained by PCR and hybridization in 28.9% of 135 HIV-infected persons at all stages of HIVinfection and only 16.4% of 61 HIV-negative immunocompromised patients. No correlation could be drawn between the detection of JCV DNA and the clinical or biological status of the HIV-positive patients. Conclusions: JCV DNA is detectable in the PBL of 28.9% of HIV-infected persons, even in the early stages of infection. JCV is more seldomly amplified in HIV-negative immunocompromised patients. Further work is in progress to determine the prognostic value of the presence of JCV DNA in the blood of HIV-positive patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:30:37