Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VASCULAR SMOOTH-MUSCLE REACTIVITY AND ENDOTHELIUM-DERIVED RELAXING FACTOR IN EXPERIMENTAL OBSTRUCTIVE-JAUNDICE
Autore:
UTKAN T; SARIOGLU Y; UTKAN NZ; GONULLU NN; YILDIRIM MK;
Indirizzi:
CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL & GEN SURG SIVAS 58140 TURKEY CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL & GEN SURG SIVAS 58140 TURKEY
Titolo Testata:
Archives of physiology and biochemistry
fascicolo: 1, volume: 104, anno: 1996,
pagine: 30 - 35
SICI:
1381-3455(1996)104:1<30:VSRAER>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORADRENALINE; ENDOTOXIN; RATS;
Keywords:
OBSTRUCTIVE JAUNDICE; EXPERIMENTAL; VASOACTIVITY; EDRF RELAXATION; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Utkan et al., "VASCULAR SMOOTH-MUSCLE REACTIVITY AND ENDOTHELIUM-DERIVED RELAXING FACTOR IN EXPERIMENTAL OBSTRUCTIVE-JAUNDICE", Archives of physiology and biochemistry, 104(1), 1996, pp. 30-35

Abstract

Obstructive jaundice is associated with a predisposition to systemic hypotension and acute renal failure. Altered vascular reactivity may contribute to the development of hypotension. In this experimental study on dogs, alterations in vascular contractile responses to noradrenaline, serotonin and KCI were investigated. Contractile responses to noradrenaline, serotonin,,, KCI and relaxation responses to papaverin andacetylcholine were provoked in isolated femoral arteries of both control dogs and animals with obstructive jaundice. In this situation concentration-response curves of noradrenaline and serotonin were blunted when compared with controls. This blunting disappeared when endothelium was removed. In rings precontracted with phenylephrine, EDRF relaxation responses to acetylcholine were increased significantly as compared to controls; at lower concentrations maximal relaxation response occured. Contractile responses to KCI and relaxation responses to papaverin did not differ between the groups, endothelium present or removed. These results indicate that obstructive jaundice induces a decrease invascular contractile responses and an increased EDRF relaxation response. We suggest that an excess in the amount of released EDRF may be one of the causes inducing systemic hypotension in obstructive jaundice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:50:50