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Titolo:
DIVERSITY OF INTRATHECAL ANTIBODY-SYNTHESIS AGAINST HTLV-I AND ITS RELATION TO HTLV-I-ASSOCIATED MYELOPATHY
Autore:
KITZE B; USUKU K; IZUMO S; NAKAMURA M; SHIRAKI H; IJICHI S; YASHIKI S; FUJIYOSHI T; SONODA S; OSAME M;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY KAGOSHIMA UNIV,CTR CHRON VIRAL DIS KAGOSHIMA JAPAN KAGOSHIMA UNIV,DEPT INTERNAL MED 3 KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,DEPT VIROL KAGOSHIMA JAPAN KYUSHU UNIV,DEPT INTERNAL MED 1 FUKUOKA 812 JAPAN FUKUOKA RED CROSS,CTR BLOOD FUKUOKA JAPAN
Titolo Testata:
Journal of neurology
fascicolo: 5, volume: 243, anno: 1996,
pagine: 393 - 400
SICI:
0340-5354(1996)243:5<393:DOIAAH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-I; TROPICAL SPASTIC PARAPARESIS; T-CELL LEUKEMIA; CYTOTOXIC LYMPHOCYTES-T; CEREBROSPINAL-FLUID; ELEVATED ANTIBODIES; IGG ANTIBODIES; HAM TSP; PEPTIDES; GLYCOPROTEINS;
Keywords:
HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE I ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS; VIRUS-SPECIFIC ANTIBODIES; IMMUNOGLOBULIN G; INTRATHECAL ANTIBODY FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
B. Kitze et al., "DIVERSITY OF INTRATHECAL ANTIBODY-SYNTHESIS AGAINST HTLV-I AND ITS RELATION TO HTLV-I-ASSOCIATED MYELOPATHY", Journal of neurology, 243(5), 1996, pp. 393-400

Abstract

The humoral immune response against human T-cell lymphotropic virus type I (HTLV-I) in the central nervous system (CNS) compartment and in the blood was investigated by enzyme immunoassay using 16 synthetic peptides corresponding to HTLV-I core and envelope sequences. We evaluated paired samples of cerebrospinal fluid and serum from HTLV-I seropositive Japanese patients, classified as follows: HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP; n = 39), patients with spinal cord disease ascribed to either HAM/TSP or to some concomitant, HTLV-I-unrelated disease (possible HAM/TSP; n = 6) or carriers withoutany clinical signs of HAM/TSP (n = 15). HTLV-I-peptide-specific intrathecal antibody synthesis was found in 79% of HAM/TSP patients, but only in 20% of carriers without HAM/TSP. The group of carriers without HAM/TSP showed local synthesis for some peptides (on average 0.3 peptides per patient). In most HAM/TSP patients, however, there was a diverse intrathecal immune response to several HTLV-I synthetic peptides (onaverage against 3.6 peptides per HAM/TSP patient), most frequently against gag p19 100-130, env gp21 458-488, and env gp46 175-199 and 288-317. The intrathecal antibody synthesis against several HTLV-I determinants may represent a pathogenic immune response in HAM/TSP and is possibly related to the infiltration of virus-infected T-cells in the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:10:46