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Titolo:
INDUCTION OF OX40, A RECEPTOR OF GP34, ON T-CELLS BY TRANS-ACTING TRANSCRIPTIONAL ACTIVATOR, TAX, OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I
Autore:
HIGASHIMURA N; TAKASAWA N; TANAKA Y; NAKAMURA M; SUGAMURA K;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU,2-1 SEIRYO MACHI SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU SENDAI MIYAGI 98077 JAPAN KITASATO UNIV,SCH MED,DEPT BIOSCI SAGAMIHARA KANAGAWA 228 JAPAN TOKYO MED & DENT UNIV,HUMAN GENE SCI CTR,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 3, volume: 87, anno: 1996,
pagine: 227 - 231
SICI:
0910-5050(1996)87:3<227:IOOARO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEATS; INTERLEUKIN-2 RECEPTOR; MONOCLONAL-ANTIBODIES; HTLV-I; LYMPHOCYTES-T; GENE; EXPRESSION; PROTEIN; P40X; TRANSFORMATION;
Keywords:
HTLV-I; TAX; OX40; OX40 LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N. Higashimura et al., "INDUCTION OF OX40, A RECEPTOR OF GP34, ON T-CELLS BY TRANS-ACTING TRANSCRIPTIONAL ACTIVATOR, TAX, OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I", Japanese journal of cancer research, 87(3), 1996, pp. 227-231

Abstract

gp34, which we had identified as a target molecule of the trans-activation by Tax of human T-cell leukemia virus type I (HTLV-I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but also OX40 can be transcriptionally activated by Tax. Three Tax-producing human T-cell lines carrying the HTLV-I genome expressed OX40 on their surfaces. Furthermore, Tax-induced transcriptional activation of OX40 was shown in Tax-inducibleJPX-9 cells. These results demonstrate that both OX40 and its ligand (gp34) are constitutively expressed on the surfaces of Tax-expressing T lymphocytes, suggesting that the OX40L/OX40 system contributes to growth stimulation of the virus-infected T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:11:44