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Titolo:
STRUCTURES OF THE RAT PROTEASOMAL ATPASES - DETERMINATION OF HIGHLY CONSERVED STRUCTURAL MOTIFS AND RULES FOR THEIR SPACING
Autore:
MAKINO Y; YOGOSAWA S; KANEMAKI M; YOSHIDA T; YAMANO K; KISHIMOTO T; MONCOLLIN V; EGLY JM; MURAMATSU M; TAMURA T;
Indirizzi:
CHIBA UNIV,FAC SCI,DEPT BIOL,INAGE KU,1-33 YAYOI CHO CHIBA 263 JAPAN CHIBA UNIV,FAC SCI,DEPT BIOL,INAGE KU CHIBA 263 JAPAN INST GENET & BIOL MOLEC & CELLULAIRE F-67404 ILLKIRCH GRAFFENS FRANCE SAITAMA MED SCH,DEPT BIOCHEM MOROYAMA SAITAMA 350 JAPAN SUMITOMO ELECT IND LTD,BIOMED R&D DEPT,SAKAE KU YOKOHAMA KANAGAWA 244JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 220, anno: 1996,
pagine: 1049 - 1054
SICI:
0006-291X(1996)220:3<1049:SOTRPA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAT-BINDING-PROTEIN; FAMILY; HELICASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y. Makino et al., "STRUCTURES OF THE RAT PROTEASOMAL ATPASES - DETERMINATION OF HIGHLY CONSERVED STRUCTURAL MOTIFS AND RULES FOR THEIR SPACING", Biochemical and biophysical research communications, 220(3), 1996, pp. 1049-1054

Abstract

We have isolated rat cDNAs for all of the five known proteasomal ATPases. The protein sequences of rat TBP1, TBP7, MSS1, S4, and SUG1 predicted from the open reading frames consist of 439, 418, 433, 440, and 406 amino acid residues, respectively, and exhibit striking similarities to each human counterpart with only several amino acid substitutions. These five rat ATPases are also highly homologous with each other. The N-terminal region in rat TBP1, TBP7, and SUG1 contains a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Also, in the central region of each rat ATPase, we found four conserved motifs, Gx4GKT, DEID, SAT, and H/QRxGRx2R, that are characteristic of a large family of ATP-dependent RNA/DNA helicases. The spacing between individual moths was strictly conserved in the rat ATPases. These findings suggest a common function of the rat proteasomal ATPases in ATP-dependent RNA/DNA unwinding. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:53:19