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Titolo:
RESPIRATORY MECHANICS IN PATIENTS VENTILATED FOR CRITICAL LUNG-DISEASE
Autore:
BEYDON L; SVANTESSON C; BRAUER K; LEMAIRE F; JONSON B;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN PHYSIOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHYSIOL S-22185 LUND SWEDEN HOP HENRI MONDOR,MED UNIT,INSERM U296 F-94010 CRETEIL FRANCE HOP HENRI MONDOR,SURG INTENS CARE UNIT,INSERM U296 F-94010 CRETEIL FRANCE
Titolo Testata:
The European respiratory journal
fascicolo: 2, volume: 9, anno: 1996,
pagine: 262 - 273
SICI:
0903-1936(1996)9:2<262:RMIPVF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED PARALYZED HUMANS; END-EXPIRATORY PRESSURE; DISTRESS SYNDROME; VOLUME DEPENDENCE; INSPIRATORY FLOW; SYSTEM MECHANICS; ARDS PATIENTS; RESISTANCE; FAILURE; PULMONARY;
Keywords:
ACUTE LUNG INJURY; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; HUMAN; LUNG; NONLINEAR MECHANICS; VISCOELASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Beydon et al., "RESPIRATORY MECHANICS IN PATIENTS VENTILATED FOR CRITICAL LUNG-DISEASE", The European respiratory journal, 9(2), 1996, pp. 262-273

Abstract

Respiratory mechanics, using flow interruption, was previously studied during the complete breath in healthy ventilated man, with numericaltechniques relieving constraints regarding flow pattern. The classical linear model of non-Newtonian behaviour was found to be valid. The present study was extended to subjects with critical lung disease. Subjects with acute lung injury (ALI; n=2), acute respiratory distress syndrome (ARDS; n=4), and chronic obstructive pulmonary disease (COPD; n=3) were studied with and without positive end-expiratory pressure (PEEP). Functional residual capacity (FRC) was measured with sulphur hexafluoride (SF6) wash-out. The static pressure-volume (P-V) curve was linear at zero end-expiratory pressure (ZEEP), but nonlinear at PEEP, Itshysteresis was nonsignificant. In ALI/ARDS, PEEP increased lung volume by distension and recruitment, but only by distension in COPD, In ALI/ARDS, resistance was increased, at ZEEP. In COPD, resistance became extremely high during expiration at ZEEP. In ALI/ARDS at ZEEP, non-Newtonian behaviour, representing tissue stress relaxation and pendel-luft, complied with the classical linear model At PEEP, the non-Newtoniancompliance became volume-dependent to an extent correlated to the nonlinearity of the static P-V curve. In COPD, non-Newtonian behaviour was adequately explained only with a model with different inspiratory and expiratory behaviour. The classical model of the respiratory system is valid in ALI/ARDS at ZEEP. More advanced models are needed at PEEP and in COPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:34:10