Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF MERIBENDAN AND RELATED HETEROCYCLIC BENZIMIDAZOLO-PYRIDAZINONES
Autore:
JONAS R; KLOCKOW M; LUES I; PRUCHER H; SCHLIEP HJ; WURZIGER H;
Indirizzi:
E MERCK AG,PRECLIN PHARMACEUT RES LABS,FRANKFURTER STR 250 W-6100 DARMSTADT GERMANY E MERCK AG,PRECLIN PHARMACEUT RES LABS,FRANKFURTER STR 250 W-6100 DARMSTADT GERMANY
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 2, volume: 28, anno: 1993,
pagine: 129 - 140
SICI:
0223-5234(1993)28:2<129:SABOMA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; POSITIVE INOTROPIC ACTIVITY; CARDIOTONIC AGENTS; HEART-FAILURE; NONSTEROIDAL CARDIOTONICS; 6-)4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES; INODILATORS; DERIVATIVES; INHIBITORS; SEARCH;
Keywords:
BENZIMIDAZOLE; CALCIUM SENSITIVITY; CARDIOTONICS; INOTROPES; PHOSPHODIESTERASE; PAPILLARY MUSCLE; PYRIDAZINONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
R. Jonas et al., "SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF MERIBENDAN AND RELATED HETEROCYCLIC BENZIMIDAZOLO-PYRIDAZINONES", European journal of medicinal chemistry, 28(2), 1993, pp. 129-140

Abstract

The synthesis of new heterocyclic benzimidazolo-pyridazinones is described. The new compounds were evaluated as inotropic agents with 'calcium-sensitizing' effects. benzimidazolyl]-2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:01:50