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Titolo:
THE INTERACTION BETWEEN KU ANTIGEN AND REF1 PROTEIN MEDIATES NEGATIVEGENE-REGULATION BY EXTRACELLULAR CALCIUM
Autore:
CHUNG U; IGARASHI T; NISHISHITA T; IWANARI H; IWAMATSU A; SUWA A; MIMORI T; HATA K; EBISU S; OGATA E; FUJITA T; OKAZAKI T;
Indirizzi:
UNIV TOKYO,SCH MED,DEPT INTERNAL MED 4,ENDOCRINE GENET & HYPERTENS UNIT,BUNKYO KU TOKYO 112 JAPAN UNIV TOKYO,SCH MED,DEPT INTERNAL MED 4,ENDOCRINE GENET & HYPERTENS UNIT,BUNKYO KU TOKYO 112 JAPAN INST IMMUNOL,BUNKYO KU TOKYO 112 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL YOKOHAMA KANAGAWA 236 JAPAN TOKYO METROPOLITAN OHTSUKA HOSP,TOSHIMA KU TOKYO 170 JAPAN KEIO UNIV,SCH MED,DEPT INTERNAL MED,SHINJUKU KU TOKYO 160 JAPAN MITSUBISHI KAGAKU BIOCLIN LAB INC,ITABASHI KU TOKYO 174 JAPAN HIGETA SHOYU CO LTD,RES LAB CHOSHI CHIBA 288 JAPAN CANC INST HOSP,TOSHIMA KU TOKYO 170 JAPAN UNIV TOKYO,SCH MED,HLTH SERV CTR,BUNKYO KU TOKYO 112 JAPAN
Titolo Testata:
The Journal of biological chemistry
fascicolo: 15, volume: 271, anno: 1996,
pagine: 8593 - 8598
SICI:
0021-9258(1996)271:15<8593:TIBKAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARATHYROID-HORMONE GENE; DNA-BINDING ACTIVITY; ESCHERICHIA-COLI; PURIFICATION; POLYPEPTIDES; MECHANISM; KINASE; REPAIR; ENDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
U. Chung et al., "THE INTERACTION BETWEEN KU ANTIGEN AND REF1 PROTEIN MEDIATES NEGATIVEGENE-REGULATION BY EXTRACELLULAR CALCIUM", The Journal of biological chemistry, 271(15), 1996, pp. 8593-8598

Abstract

Through the specific binding of a negative calcium-responsive elementto its binding protein in response to extracellular Ca (Ca-e(2+)), negative calcium-responsive element-bearing genes, such as the human parathyroid hormone gene, are negatively regulated by Ca-e(2+). The Ku antigen mediated negative gene regulation by Ca-e(2+) by interacting with a redox factor protein, REF1. Although sequence-nonspecific DNA binding activity of the Ku antigen has been well characterized, the mechanism of its sequence-specific DNA binding remained obscure. Here, we report that the specific binding of the Ku antigen to another protein, REF1, leads to DNA-protein complex formation with a novel sequence specificity and thereby regulates gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:12:09