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Titolo:
STRESS-INDUCED AND YOHIMBINE-INDUCED RELEASE OF CHOLECYSTOKININ IN THE FRONTAL-CORTEX OF THE FREELY MOVING RAT - PREVENTION BY DIAZEPAM BUTNOT ONDANSETRON
Autore:
NEVO I; BECKER C; HAMON M; BENOLIEL JJ;
Indirizzi:
UNIV PARIS 06,FAC MED PITIE SALPETRIERE,INSERM U288,91 BLVD HOP F-75634 PARIS 13 FRANCE UNIV PARIS 06,FAC MED PITIE SALPETRIERE,INSERM U288 F-75634 PARIS 13 FRANCE
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 66, anno: 1996,
pagine: 2041 - 2049
SICI:
0022-3042(1996)66:5<2041:SAYROC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; RECEPTOR ANTAGONISTS; ANXIOLYTIC ACTIVITY; MESSENGER-RNA; SPINAL-CORD; X-MAZE; BRAIN; ANXIETY; MICRODIALYSIS; IMMUNOREACTIVITY;
Keywords:
CHOLECYSTOKININ-LIKE MATERIAL; STRESS; ANXIOLYTICS; MICRODIALYSIS; FRONTAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
I. Nevo et al., "STRESS-INDUCED AND YOHIMBINE-INDUCED RELEASE OF CHOLECYSTOKININ IN THE FRONTAL-CORTEX OF THE FREELY MOVING RAT - PREVENTION BY DIAZEPAM BUTNOT ONDANSETRON", Journal of neurochemistry, 66(5), 1996, pp. 2041-2049

Abstract

The in vivo release of cholecystokinin (CCK)like material (CCKLM) wasmeasured in the frontal cortex of freely moving rats using the microdialysis technique combined with a sensitive radioimmunoassay. Local perfusion of K+ (100 mM)-enriched artificial CSF resulted in a 10-fold increase in CCKLM outflow, as compared with that occurring under basal resting (K+ = 3.0 mM) conditions, and this effect could be completely prevented by removal of Ca2+ in the perfusing fluid. Chromatographic analyses demonstrated that CCK-8S contributed to 70% of CCKLM. Stressful stimuli such as a 2-min exposure to diethyl ether and a 30-min restraint produced a marked but transient increase in cortical CCKLM release. In addition, anxiety-like behavior induced by the systemic administration of yohimbine (5 mg/kg i.p.) was associated with a long-lasting enhancement in the peptide outflow. Pretreatment with the potent anxiolytic drug diazepam (5 mg/kg i.p., 5 min before each condition), whichexerted no effect on its own, completely prevented CCKLM overflow dueto diethyl ether, restraint, or yohimbine administration. In contrast, neither the systemic injection (0.1 mg/kg i.p.) nor the local application (100 mu M through the microdialysis probe) of the serotonin 5-HT3 antagonist ondansetron affected the increased release of CCKLM in rats restrained for 30 min or treated with yohimbine. These results indicate that cortical CCKergic neurotransmission is increased during stress or anxiety-like behavior in rats, Prevention of this effect by diazepam suggests that an inhibitory influence of benzodiazepines on cortical CCKergic neurons might participate in the anxiolytic action of these drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:30:02