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Titolo:
PREPARATION AND PRELIMINARY BIOLOGICAL EVALUATION OF [F-18] NCQ-115 -A NEW SELECTIVE REVERSIBLE DOPAMINE D2 RECEPTOR LIGAND
Autore:
NAJAFI A; PETERSON A; BUCHSBAUM M; ODELL S; WEIHMULLER F;
Indirizzi:
UNIV CALIF IRVINE,CTR BRAIN IMAGING,DEPT PSYCHIAT IRVINE CA 92717 UNIV CALIF IRVINE,DEPT PSYCHOBIOL IRVINE CA 92717
Titolo Testata:
Nuclear medicine and biology
fascicolo: 4, volume: 20, anno: 1993,
pagine: 549 - 555
SICI:
0969-8051(1993)20:4<549:PAPBEO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN-BRAIN; SUBSTITUTED BENZAMIDE; BINDING-PROPERTIES; PET; BABOON; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Najafi et al., "PREPARATION AND PRELIMINARY BIOLOGICAL EVALUATION OF [F-18] NCQ-115 -A NEW SELECTIVE REVERSIBLE DOPAMINE D2 RECEPTOR LIGAND", Nuclear medicine and biology, 20(4), 1993, pp. 549-555

Abstract

F-18-labeled dopamine D2 antagonist, NCQ-115 yl)-2-pyrrolidinyl)methyl-2,3-dimethoxybenzamide), was successfully prepared using a remotely controlled system. [F-18]Fluoride was reacted with the trifluoromethanesulfonate salt of 4-(trimethylamino)benzaldehyde. The product was first reduced with LAH, and then reacted with thionyl bromide to yield F-18-labeled 4-fluorobenzylbromide. [F-18]4-Fluorobenzylbromide was thenreacted with the pyrrolidine precursor (NCQ-282) to yield the product[F-18]NCQ-115 contaminated with unreacted starting material. The product was purified by reverse phase chromatography yielding [F-18]NCQ-115 with a specific activity of more than 1400 Ci/mmol. Autoradiographicand biodistribution data following injection of [F-18]NCQ-115 in ratsrevealed the regional uptake of striatum/cerebellum to be 3.2 at 30 min post-injection.

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Documento generato il 17/01/20 alle ore 20:24:35