Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TEMPORAL PATTERNS OF AFLATOXIN-ALBUMIN ADDUCTS IN HEPATITIS-B SURFACEANTIGEN-POSITIVE AND ANTIGEN-NEGATIVE RESIDENTS OF DAXIN, QIDONG COUNTY, PEOPLES-REPUBLIC-OF-CHINA
Autore:
WANG JS; QIAN GS; ZARBA A; HE X; ZHU YR; ZHANG BC; JACOBSON L; GANGE SJ; MUNOZ A; KENSLER TW; GROOPMAN JD;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,615 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 21205 SHANGHAI CANC INST SHANGHAI 200032 PEOPLES R CHINA QIDONG LIVER CANC INST QIDONG JIANGSU PEOPLES R CHINA
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 4, volume: 5, anno: 1996,
pagine: 253 - 261
SICI:
1055-9965(1996)5:4<253:TPOAAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR-CARCINOMA; MOLECULAR DOSIMETRY; CHEMICAL CARCINOGENS; GAMBIAN CHILDREN; PLASMA-ALBUMIN; WEST AFRICA; EXPOSURE; EPIDEMIOLOGY; ENZYMES; VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Wang et al., "TEMPORAL PATTERNS OF AFLATOXIN-ALBUMIN ADDUCTS IN HEPATITIS-B SURFACEANTIGEN-POSITIVE AND ANTIGEN-NEGATIVE RESIDENTS OF DAXIN, QIDONG COUNTY, PEOPLES-REPUBLIC-OF-CHINA", Cancer epidemiology, biomarkers & prevention, 5(4), 1996, pp. 253-261

Abstract

Molecular epidemiological studies of populations at high risk for liver cancer have shown that hepatitis B virus (HBV) and aflatoxin B-1(AFB(1)) exposure are two major risk factors for this disease. These etiological agents, combined with nutritional deficiencies, are important for the initiation and promotion of liver cancer in various parts of the world. In Qidong, People's Republic of China, liver cancer accountsfor 10% of all adult deaths, and both HBV and AFB, exposures are common. To study temporal and possible chemical-viral interactions in people, serum samples were collected during a longitudinal study designed to measure aflatoxin molecular biomarkers in residents of Daxin Township, Qidong City, People's Republic of China. In this study, the temporal modulation of aflatoxin adduct formation with albumin over multiplelifetimes of serum albumin was examined in both HBV-positive and HBV-negative people in two periods: September-December 1993 (wave 1) and June-September 1994 (wave 2). During the 12-week monitoring period of wave 1, 120 individuals (balanced by gender and HBV status) provided a total of 792 blood samples. AFB(1)-albumin adducts were detected in all but one of the serum samples. The range of binding detected by RIA. in the Daxin population was 0.17-4.39 pmol AFB(11)/mg albumin with an overall mean +/- SD of 1.51 +/- 0.21 pmol AFB(11)/mg albumin. The meana SD for weeks 0, 2, 4, 6, 8, 10, and 12 of wave 1 were 1.21 +/- 0.41, 1.58 +/- 0.70, 1.36 +/- 0.52, 1.71 +/- 0.44, 1.18 +/- 0.60, 2.00 +/-0.59, and 1.68 +/- 0.34 pmol AFB(1)/mg albumin, respectively. During wave 2, 103 individuals from wave 1 provided a total of 396 blood samples collected monthly over wave 2, with mean +/- SD aflatoxin-albumin adduct levels of 1.19 +/- 0.37, 0.85 +/- 0.45, 0.89 +/- 0.28, and 0.61+/- 0.15 pmol AFB(1)/mg albumin. Using linear regression models, the mean aflatoxin-albumin adduct levels increased (P < 0.05) during the 12 weeks of wave 1 and decreased (P < 0.05) over the 4 months of wave 2. Neither HBV surface antigen status nor gender modified either the baseline mean or the temporal trend. Highperformance liquid chromatography confirmation was done on a subset of serum samples, and the resultsshow an excellent association between the immunoassay data and high-performance liquid chromatography. Taken together, these data demonstrate that AFB(1)-albumin is a sensitive and specific biomarker for assessing exposure to this carcinogen in the population in Qidong.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:46:38