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Titolo:
CAROTID-SINUS NERVE-TERMINALS WHICH ARE TYROSINE-HYDROXYLASE IMMUNOREACTIVE ARE FOUND IN THE COMMISSURAL NUCLEUS OF THE TRACTUS-SOLITARIUS
Autore:
MASSARI VJ; SHIRAHATA M; JOHNSON TA; GATTI PJ;
Indirizzi:
HOWARD UNIV,COLL MED,DEPT PHARMACOL WASHINGTON DC 20059 HOWARD UNIV,COLL MED,DEPT VET SCI WASHINGTON DC 20059 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI BALTIMORE MD 21205
Titolo Testata:
Journal of neurocytology
fascicolo: 3, volume: 25, anno: 1996,
pagine: 197 - 208
SICI:
0300-4864(1996)25:3<197:CNWATI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SENSORY NEURONS; BRAIN-STEM PROJECTIONS; HORSERADISH-PEROXIDASE; SYNAPTIC INTERACTION; VAGAL AFFERENTS; CATECHOLAMINERGIC NEURONS; WGA-HRP; CAT; RAT; BARORECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
V.J. Massari et al., "CAROTID-SINUS NERVE-TERMINALS WHICH ARE TYROSINE-HYDROXYLASE IMMUNOREACTIVE ARE FOUND IN THE COMMISSURAL NUCLEUS OF THE TRACTUS-SOLITARIUS", Journal of neurocytology, 25(3), 1996, pp. 197-208

Abstract

Tyrosine hydroxylase immunoreactive sensory neurons in the petrosal ganglion selectively innervate the carotid body via the carotid sinus nerve. Central projections of the carotid sinus nerve were traced with horseradish peroxidase. The commissural nucleus of the tractus solitarius was examined by dual labelling light and electron microscopy. Dense bilateral labelling with horseradish peroxidase was found in the tractus solitarius and commissural nucleus of the tractus solitarius. Horseradish peroxidase was found in unmyelinated axons, myelinated axons,and nerve terminals. About 88% of horseradish peroxidase-labelled carotid sinus nerve axons were unmyelinated. Tyrosine hydroxylase immunoreactivity was identified in unmyelinated axons, myelinated axons, dendrites, perikarya, and nerve terminals. Most tyrosine hydroxylase immunoreactive axons (93%) in the commissural nucleus of the tractus solitarius were unmyelinated. Tyrosine hydroxylase immunoreactivity was simultaneously identified in carotid sinus nerve unmyelinated axons, myelinated axons, and nerve terminals. These double-labelled terminals comprised 28% of the number of tyrosine hydroxylase immunoreactive terminals in the commissural nucleus of the tractus solitarius, and 55% of transganglionically-labelled terminals. Therefore, there are both central and peripheral sources of tyrosine hydroxylase immunoreactive nerve terminals in the commissural nucleus of the tractus solitarius. These data support the hypothesis that peripheral tyrosine hydroxylase immunoreactive neurons are involved in the origination of the chemoreceptorreflex. Axo-axonic synapses between peripheral carotid sinus nerve afferent terminals and central terminals containing tyrosine hydroxylaseimmunoreactivity were observed in 22% of the axo-axonic synapses observed. Thus, central tyrosine hydroxylase immunoreactivity neurons are involved in the modulation of the chemo- and/or baroreceptor reflexes. Synaptic contacts were not observed between carotid sinus nerve afferents and tyrosine hydroxylase immunoreactive perikarya of dendrites. Catecholaminergic neurons are thus unlikely to be the second order neurons of either the chemo- or baroreceptor reflex in the commissural nucleus of the tractus solitarius.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:23:55