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Titolo:
PROSPECTIVE EVALUATION OF FECAL FATTY-ACID EXCRETION IN SHORT-BOWEL SYNDROME IN NEWBORNS
Autore:
HEINEMAN E; DEJONG CHC; PIENASPOEL M; LIEFAARD G; MOLENAAR JC; TIBBOEL D;
Indirizzi:
SOPHIA CHILDRENS UNIV HOSP,DEPT PAEDIAT SURG,DR MOLEWATERPLEIN 60 3015 GJ ROTTERDAM NETHERLANDS SOPHIA CHILDRENS UNIV HOSP,DEPT PAEDIAT SURG 3015 GJ ROTTERDAM NETHERLANDS UNIV LIMBURG HOSP,DEPT SURG MAASTRICHT NETHERLANDS
Titolo Testata:
Journal of pediatric surgery
fascicolo: 4, volume: 31, anno: 1996,
pagine: 520 - 525
SICI:
0022-3468(1996)31:4<520:PEOFFE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-INTESTINAL-MUCOSA; DIETARY-FAT; ADAPTATION; RESECTION; RAT; ENTEROGLUCAGON; HYPERPLASIA; INFANTS; RELEASE; GUT;
Keywords:
SHORT BOWEL SYNDROME; INTESTINAL TRACT; ADAPTATION; NEONATE; FATTY ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
E. Heineman et al., "PROSPECTIVE EVALUATION OF FECAL FATTY-ACID EXCRETION IN SHORT-BOWEL SYNDROME IN NEWBORNS", Journal of pediatric surgery, 31(4), 1996, pp. 520-525

Abstract

Short bowel syndrome (SBS) in the newborn results in limited intestinal absorptive capacity, leading especially to fatty acid (FA) malabsorption. It is unknown whether adaptation occurs in time in FA absorption, and whether this adaptation is chain-length dependent. The aim of the present study was to prospectively evaluate FA absorption and excretion during SBS in the newborn. Twenty-one neonates who underwent small bower resection (of variable length) for various reasons (necrotizing enterocolitis, intestinal atresia, meconium peritonitis, cloacal extrophy, etc) were studied. Eight neonates had SBS, defined as a small bowel remnant of less than 50% of the original small bowel length related to gestational age. The mean remaining small bowel length in the SBS group was 34% (24% to 42%). The non-SBS control group consisted of 13 neonates who had only minor small bowel resections. The mean remaining bower length for the non-SBS group was 95% (70% to 100%). The results show that the total fractional excretion of FA (FE-FA) at 2 weeks and 1, 2, 3, and 4 months postsurgery was 51% +/- 37%, 33% +/- 24%, 51%+/- 65%, 53% +/- 27%, and 7% +/- 2% in patients with SBS, versus 12% /- 8%, 24% +/- 10%, 9% +/- 3%, 8% +/- 3% and 17% +/- 14% in the non-SBS controls, respectively (P < .05 by ANOVA). There appeared to be an amelioration in time in FA absorption, especially in the SBS group, after 3 months. FE-FA was chain-length related, being considerably less for C10 and C12 than for C14 and longer amounts. An amelioration of absorption occurred in the SBS patients, especially with the longer-chain FA. On the basis of the study data, the authors conclude that in theinitial adaptation phase shorter chain lengths are better absorbed than longer chain lengths; however, in the latter FA group, substantial adaptation occurs with time. (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:03:23